FREQUENCY AND CHARACTERISTICS OF INTRAOCULAR INFLAMMATION AFTER AFLIBERCEPT INJECTION

被引：22

作者：

Fine, Howard F. ^{[1
]}

Roth, Daniel B. ^{[1
]}

Shah, Sumit P. ^{[1
]}

Haque, Tahia ^{[1
]}

Wheatley, Matthew ^{[1
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, Dept Ophthalmol, New Brunswick, NJ 08901 USA

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2015年 / 35卷 / 04期

关键词：

aflibercept; endophthalmitis; intravitreal injection; noninfectious endophthalmitis; uveitis; INTRAVITREAL INJECTION; MACULAR DEGENERATION; RANIBIZUMAB INJECTIONS; BEVACIZUMAB; SAFETY; VERTEPORFIN;

D O I：

10.1097/IAE.0000000000000398

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report the frequency and characteristics of intraocular inflammation after intravitreal aflibercept injection. Methods: A single-center retrospective study was performed in patients who received intravitreal aflibercept from November 2011 through June 2013. Results: There were 28 cases of intraocular inflammation after a total of 5,905 aflibercept injections among 1,660 patients. The mean baseline acuity was 20/57, which decreased to 20/179 at diagnosis (P < 0.0001) but recovered to 20/59 at Month 1, 20/57 at Month 3, and 20/52 at Month 6 (P = not significant). Vitreous culture and injection of antibiotics were performed in eight cases, and all were culture negative; the remainder received only topical corticosteroids. Conclusion: The frequency of inflammation after aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroid treatment.

引用

页码：681 / 686

页数：6

共 22 条

[1] Ranibizumab versus verteporfin for neovascular age-related macular degeneration [J].

Brown, David M. ;

Kaiser, Peter K. ;

Michels, Mark ;

Soubrane, Gisele ;

Heier, Jeffrey S. ;

Kim, Robert Y. ;

Sy, Judy P. ;

Schneider, Susan .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (14) :1432-1444

[2] CHARACTERIZATION OF STERILE INTRAOCULAR INFLAMMATORY RESPONSES AFTER INTRAVITREAL BEVACIZUMAB INJECTION [J].

Chong, Deborah Y. ;

Anand, Rajiv ;

Williams, Patrick D. ;

Qureshi, Jawad A. ;

Callanan, David G. .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2010, 30 (09) :1432-1440

[3] Intraocular inflammation after intravitreal ranibizumab injections [J].

Fauser, Sascha ;

Schroeder, Sabine ;

Caramoy, Albert ;

Kirchhof, Bernd ;

Lappas, Alexandra .

ACTA OPHTHALMOLOGICA, 2011, 89 (01) :E98-E99

[4] The International Intravitreal Bevacizumab Safety Survey: using the Internet to assess drug safety worldwide [J].

Fung, A. E. ;

Rosenfeld, P. J. ;

Reichel, E. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2006, 90 (11) :1344-1349

[5] Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin) [J].

Georgopoulos, M. ;

Polak, K. ;

Prager, F. ;

Pruente, C. ;

Schmidt-Erfurth, U. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2009, 93 (04) :457-462

[6] Aflibercept-Related Sterile Inflammation [J].

Hahn, Paul ;

Kim, Judy E. ;

Stinnett, Sandra ;

Chung, Mina M. ;

Dugel, Pravin U. ;

Flynn, Harry W., Jr. ;

Huang, Suber S. ;

Sadda, SriniVas R. ;

Mahmoud, Tamer H. .

OPHTHALMOLOGY, 2013, 120 (05) :1100-1101

[7] Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration - Year 1 results of the FOCUS study [J].

Heier, Jeffrey S. ;

Boyer, David S. ;

Ciulla, Thomas A. ;

Ferrone, Philip J. ;

Jumper, J. Michael ;

Gentile, Ronald C. ;

Kotlovker, Debbi ;

Chung, Carol Y. ;

Kim, Robert Y. .

ARCHIVES OF OPHTHALMOLOGY, 2006, 124 (11) :1532-1542

[8]

Holladay JT, 1997, J REFRACT SURG, V13, P388

[9] Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents [J].

Jin, Tuo ;

Zhu, Hahao ;

Wu, Fei ;

Yuan, Weien ;

Geng, Lee L. ;

Zhu, Hua .

JOURNAL OF CONTROLLED RELEASE, 2008, 128 (01) :50-59

[10] Incidence and characteristics of acute intraocular inflammation after intravitreal injection of bevacizumab: a retrospective cohort study [J].

Johnson, Davin ;

Hollands, Hussein ;

Hollands, Simon ;

Sharma, Sanjay .

CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2010, 45 (03) :239-242

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