FREQUENCY AND CHARACTERISTICS OF INTRAOCULAR INFLAMMATION AFTER AFLIBERCEPT INJECTION

被引:20
作者
Fine, Howard F. [1 ]
Roth, Daniel B. [1 ]
Shah, Sumit P. [1 ]
Haque, Tahia [1 ]
Wheatley, Matthew [1 ]
机构
[1] Rutgers Robert Wood Johnson Med Sch, Dept Ophthalmol, New Brunswick, NJ 08901 USA
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2015年 / 35卷 / 04期
关键词
aflibercept; endophthalmitis; intravitreal injection; noninfectious endophthalmitis; uveitis; INTRAVITREAL INJECTION; MACULAR DEGENERATION; RANIBIZUMAB INJECTIONS; BEVACIZUMAB; SAFETY; VERTEPORFIN;
D O I
10.1097/IAE.0000000000000398
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To report the frequency and characteristics of intraocular inflammation after intravitreal aflibercept injection. Methods: A single-center retrospective study was performed in patients who received intravitreal aflibercept from November 2011 through June 2013. Results: There were 28 cases of intraocular inflammation after a total of 5,905 aflibercept injections among 1,660 patients. The mean baseline acuity was 20/57, which decreased to 20/179 at diagnosis (P < 0.0001) but recovered to 20/59 at Month 1, 20/57 at Month 3, and 20/52 at Month 6 (P = not significant). Vitreous culture and injection of antibiotics were performed in eight cases, and all were culture negative; the remainder received only topical corticosteroids. Conclusion: The frequency of inflammation after aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroid treatment.
引用
收藏
页码:681 / 686
页数:6
相关论文
共 22 条
  • [1] Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    Brown, David M.
    Kaiser, Peter K.
    Michels, Mark
    Soubrane, Gisele
    Heier, Jeffrey S.
    Kim, Robert Y.
    Sy, Judy P.
    Schneider, Susan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (14) : 1432 - 1444
  • [2] CHARACTERIZATION OF STERILE INTRAOCULAR INFLAMMATORY RESPONSES AFTER INTRAVITREAL BEVACIZUMAB INJECTION
    Chong, Deborah Y.
    Anand, Rajiv
    Williams, Patrick D.
    Qureshi, Jawad A.
    Callanan, David G.
    [J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2010, 30 (09): : 1432 - 1440
  • [3] Intraocular inflammation after intravitreal ranibizumab injections
    Fauser, Sascha
    Schroeder, Sabine
    Caramoy, Albert
    Kirchhof, Bernd
    Lappas, Alexandra
    [J]. ACTA OPHTHALMOLOGICA, 2011, 89 (01) : E98 - E99
  • [4] The International Intravitreal Bevacizumab Safety Survey: using the Internet to assess drug safety worldwide
    Fung, A. E.
    Rosenfeld, P. J.
    Reichel, E.
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2006, 90 (11) : 1344 - 1349
  • [5] Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin)
    Georgopoulos, M.
    Polak, K.
    Prager, F.
    Pruente, C.
    Schmidt-Erfurth, U.
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2009, 93 (04) : 457 - 462
  • [6] Aflibercept-Related Sterile Inflammation
    Hahn, Paul
    Kim, Judy E.
    Stinnett, Sandra
    Chung, Mina M.
    Dugel, Pravin U.
    Flynn, Harry W., Jr.
    Huang, Suber S.
    Sadda, SriniVas R.
    Mahmoud, Tamer H.
    [J]. OPHTHALMOLOGY, 2013, 120 (05) : 1100 - 1101
  • [7] Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration - Year 1 results of the FOCUS study
    Heier, Jeffrey S.
    Boyer, David S.
    Ciulla, Thomas A.
    Ferrone, Philip J.
    Jumper, J. Michael
    Gentile, Ronald C.
    Kotlovker, Debbi
    Chung, Carol Y.
    Kim, Robert Y.
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2006, 124 (11) : 1532 - 1542
  • [8] Holladay JT, 1997, J REFRACT SURG, V13, P388
  • [9] Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    Jin, Tuo
    Zhu, Hahao
    Wu, Fei
    Yuan, Weien
    Geng, Lee L.
    Zhu, Hua
    [J]. JOURNAL OF CONTROLLED RELEASE, 2008, 128 (01) : 50 - 59
  • [10] Incidence and characteristics of acute intraocular inflammation after intravitreal injection of bevacizumab: a retrospective cohort study
    Johnson, Davin
    Hollands, Hussein
    Hollands, Simon
    Sharma, Sanjay
    [J]. CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2010, 45 (03): : 239 - 242