c-MET EXPRESSION AS AN INDICATOR OF SURVIVAL OUTCOME IN PATIENTS WITH ORAL TONGUE CARCINOMA

被引：34

作者：

Kim, Chul-Ho ^{[2
]}

Koh, Yoon Woo ^{[3
]}

Han, Jae Ho ^{[4
]}

Kim, Jae Wook ^{[3
]}

Lee, Jin Seok ^{[2
]}

Baek, Seung Jae ^{[5
]}

Hwang, Hye Sook ^{[2
]}

Choi, Eun Chang ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul, South Korea

[2] Ajou Univ, Sch Med, Dept Otolaryngol, Suwon 441749, South Korea

[3] Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Puchon, South Korea

[4] Ajou Univ, Sch Med, Dept Pathol, Suwon 441749, South Korea

[5] Kwandong Univ, Coll Med, Dept Otorhinolaryngol, Koyang, South Korea

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 12期

关键词：

oral tongue cancer; hepatocyte growth factor (HGF); c-Met; prognosis; HEPATOCYTE GROWTH-FACTOR; SQUAMOUS-CELL-CARCINOMA; FACTOR-RECEPTOR; HYPOPHARYNGEAL CARCINOMA; SCATTER FACTOR; IN-VITRO; STAGE-I; METASTASIS; CANCER; HEAD;

D O I：

10.1002/hed.21383

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCOOT). Methods. Tumors from 61 patients with SCOOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCOOT. Results. The positive rates of HGF and c-Met immunostaining in SCOOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion. The c-Met expression may play an important role in the progression and the survival outcome of patients with SCOOT. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1655-1664, 2010

引用

页码：1655 / 1664

页数：10

共 40 条

[21] HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer [J].

Knowles, Lynn M. ;

Stabile, Laura P. ;

Egloff, Ann Marie ;

Rothstein, Mary E. ;

Thomas, Sufi M. ;

Gubish, Christopher T. ;

Lerner, Edwina C. ;

Seethala, Raja R. ;

Suzuki, Shinsuke ;

Quesnelle, Kelly M. ;

Morgan, Sarah ;

Ferris, Robert L. ;

Grandis, Jennifer R. ;

Siegfried, Jill M. .

CLINICAL CANCER RESEARCH, 2009, 15 (11) :3740-3750

[22] The Sema domain of Met is necessary for receptor dimerization and activation [J].

Kong-Beltran, M ;

Stamos, J ;

Wickramasinghe, D .

CANCER CELL, 2004, 6 (01) :75-84

[23] (-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells [J].

Lim, Young Chang ;

Park, Hun Yi ;

Hwang, Hye Sook ;

Kang, Sung Un ;

Pyun, Jung Hee ;

Lee, Mi Hye ;

Choi, Eun Chang ;

Kim, Chul-Ho .

CANCER LETTERS, 2008, 271 (01) :140-152

[24] Overexpression of scatter factor and its receptor (c-met) in oral squamous cell carcinoma [J].

Marshall, DD ;

Kornberg, LJ .

LARYNGOSCOPE, 1998, 108 (09) :1413-1417

[25]

Matsumoto K, 1996, J BIOCHEM-TOKYO, V119, P591

[26] IDENTIFICATION OF A FIBROBLAST-DERIVED EPITHELIAL MORPHOGEN AS HEPATOCYTE GROWTH-FACTOR [J].

MONTESANO, R ;

MATSUMOTO, K ;

NAKAMURA, T ;

ORCI, L .

CELL, 1991, 67 (05) :901-908

[27] K252a inhibits the oncogenic properties of Met, the HGF receptor [J].

Morotti, A ;

Mila, S ;

Accornero, P ;

Tagliabue, E ;

Ponzetto, C .

ONCOGENE, 2002, 21 (32) :4885-4893

[28]

Nakajima M, 1999, CANCER, V85, P1894

[29] MOLECULAR-CLONING AND EXPRESSION OF HUMAN HEPATOCYTE GROWTH-FACTOR [J].

NAKAMURA, T ;

NISHIZAWA, T ;

HAGIYA, M ;

SEKI, T ;

SHIMONISHI, M ;

SUGIMURA, A ;

TASHIRO, K ;

SHIMIZU, S .

NATURE, 1989, 342 (6248) :440-443

[30]

Ries L, 1991, CANC STAT REV 1973 1

← 1 2 3 4 →