Decision-making in the management of adult classical Hodgkin's lymphoma: determining the optimal treatment

被引：2

作者：

Nicolas, Mounier ^{[1
]}

Christian, Gisselbrecht ^{[2
]}

机构：

[1] Archet Hosp, Oncohematol Dept, Nice, France

[2] Hop St Louis, Inst Hematol, Paris, France

来源：

EXPERT REVIEW OF HEMATOLOGY | 2015年 / 8卷 / 02期

关键词：

chemotherapy; Hodgkin; molecular profiles; PET imaging; targeted drugs; transplantation; POSITRON-EMISSION-TOMOGRAPHY; STEM-CELL TRANSPLANTATION; INTERNATIONAL PROGNOSTIC SCORE; BRENTUXIMAB VEDOTIN; STANFORD-V; OPEN-LABEL; STAGE; CHEMOTHERAPY; HIV; ABVD;

D O I：

10.1586/17474086.2015.995622

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review discusses promising new approaches in classical Hodgkin's lymphoma that have been recently evaluated. There is a focus on the fluorodeoxyglucose PET scanning that is now considered crucial for staging and treatment evaluation, including interim evaluation after two cycles. An up-front treatment strategy is discussed, with the place of radiation therapy and the difficult choice of chemotherapy intensity emphasized. Indications for frail patients are also reviewed, particularly elderly or HIV-positive patients. Emerging data on the antibody drug conjugate brentuximab vedotin and its future potential in the transplantation framework for relapsed/refractory Hodgkin's lymphoma is also discussed.

引用

页码：205 / 216

页数：12

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