Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells

This study focused the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of tomato plant cultivars (Caramba, Valentine, Negro, Abuela, and Anairis). AE, HME and AcE extracts of all cultivars reduced cell viability, IC50 values ranging from 9 +/- 2 to 55 +/- 11, from 103 +/- 25 to 171 +/- 29 and from 291 +/- 26 to 459 +/- 14 mu g mL(-1), respectively. Moreover, both HME and AcE extracts scavenged (NO)-N-center dot (IC50 values ranged from 0.87 +/- 0.12 to 1.54 +/- 0.23 and from 0.90 +/- 0.01 to 2.23 +/- 0.14 mg mL(-1), respectively), but only HMEs was able to scavenge O-2(center dot-) showing IC50 values from 0.12 +/- <= 0.01 to 0.43 +/- 0.08 mg mL(-1). Our results demonstrate that tomato leaves, a by-product of tomato processing industry, are a valuable source of bioactive compounds, providing beneficial properties for human health. (C) 2017 Elsevier Ltd. All rights reserved.