BNT162b2 mRNA COVID-19 Vaccine Effectiveness in the Prevention of SARS-CoV-2 Infection: A Preliminary Report

被引：24

作者：

Bianchi, Francesco Paolo ^{[1
]}

Germinario, Cinzia Annatea ^{[1
]}

Migliore, Giovanni ^{[2
]}

Vimercati, Luigi ^{[3
]}

Martinelli, Andrea ^{[1
]}

Lobifaro, Annamaria ^{[1
]}

Tafuri, Silvio ^{[1
]}

Stefanizzi, Pasquale ^{[1
]}

机构：

[1] Aldo Moro Univ Bari, Dept Biomed Sci & Human Oncol, Piazza Giulio Cesare 11, I-70124 Bari, Italy

[2] Bari Policlin Gen Hosp, Bari, Italy

[3] Aldo Moro Univ Bari, Dept Interdisciplinary Med, Bari, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 03期

关键词：

COVID-19; documented infection; vaccine effectiveness; healthcare workers;

D O I：

10.1093/infdis/jiab262

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the preregistration trial, data on efficacy of BNT162b2 mRNA vaccine against SARS-CoV-2 infection were not collected. This study aimed to evaluate vaccine effectiveness (VE) against documented infection. Bari Policlinico University Hospital health care workers (HCWs) who completed the vaccination schedule were matched with HCWs who had refused vaccination. VE for documented infection was 61.9% (95% confidence interval [CI], 19.2%-82.0%) 14-20 days after first dose, 87.9% (95% CI, 51.7%-97.0%) 21-27 days after first dose, and 96.0% (95% CI, 82.2%-99.1%) 7 or more days after second dose. Unvaccinated HCWs remain a concern in the context of the pandemic emergency.

引用

页码：431 / 434

页数：4

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