Reconstruction of cellular signalling networks and analysis of their properties

被引：334
作者：
Papin, JA
Hunter, T
Palsson, BO
Subramaniam, S
机构：
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA
[3] Salk Inst Biol Studies, Mol & Cellular Biol Lab, La Jolla, CA 92037 USA
[4] Univ Calif San Diego, San Diego Supercomp Ctr, Dept Chem & Biochem, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1570
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.
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页码：99 / 111
页数：13
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