Modification of the synaptic glutamate turnover in the hippocampal tissue exposed to low-frequency, pulsed magnetic fields

被引：19

作者：

Wieraszko, A ^{[1
]}

Armani, J ^{[1
]}

Maqsood, N ^{[1
]}

Raja, H ^{[1
]}

Philip, S ^{[1
]}

机构：

[1] CUNY Coll Staten Isl, Dept Biol, Neurosci Program, Staten Isl, NY 10314 USA

来源：

BRAIN RESEARCH | 2005年 / 1052卷 / 02期

关键词：

hippocampus; magnetic field; glutamate turnover;

D O I：

10.1016/j.brainres.2005.06.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of pulsed magnetic fields (PMF) on the release and uptake of glutamate was investigated. While the release was examined using hippocampal slices, synaptosomes were chosen to characterize the uptake process. H-3-D-aspartate was used as a marker of glutamergic transmission. The pulsed magnetic fields (9-15 mT) applied according to the pattern Which induced epileptic discharges in hippocampus amplified and attenuated the release and uptake of glutamate, respectively. However. the magnetic fields which induced an increase in neuronal excitability without concomitant seizures amplified both processes. These results confirm our previous reports and indicate that the glutamergic synapses are the target of magnetic fields action. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：232 / 235

页数：4

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