Stereoselective synthesis of 4-substituted 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

被引：4
作者：
Golantsov, NE
Karchava, AV
Nosova, VM
Yurovskaya, MA
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia
[2] State Sci Ctr Russian Fed, State Res Inst Chem Technol Organoelement Cpds, Moscow 111123, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2005年 / 54卷 / 01期
关键词：
1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles; 1,2,3,4-tetrahydropyrazino[1,2-a]indoles; N-substituted indoles; reduction of nitrites; 2-cyanoindole; Mitsunobu reaction;
D O I：
10.1007/s11172-005-0241-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
4-Substituted 1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized from 2-cyano-indole. (R)-4-Methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole was obtained by the Mitsunobu reaction. Stereoselective reduction of 4-substituted 1,2,3,4-tetrahydropyrazino[1,2-a]indoles gave 4-substituted 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles. (4R,10aR)-4-Methyl-1,2,3,4, 10, 10a-hexahydropyrazino[1,2-a]indole was synthesized.
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收藏
页码：226 / 230
页数：5
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