Streptococcusthermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

被引：39

作者：

Dargahi, Narges ^{[1
]}

Matsoukas, John ^{[2
]}

Apostolopoulos, Vasso ^{[1
]}

机构：

[1] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic 3030, Australia

[2] NewDrug, Patras Sci Pk, Patras 26500, Greece

来源：

BRAIN SCIENCES | 2020年 / 10卷 / 02期

关键词：

probiotics; Streptococcus thermophilus; ST285; MBP83-99; peptide; mannan; immune modulation; multiple sclerosis; agonist peptide; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IMMUNE-RESPONSES; MANNAN; PROBIOTICS; MBP83-99; CONJUGATION; MICROBIOTA; EXPRESSION; DESIGN; CELLS;

D O I：

10.3390/brainsci10020126

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of Streptococcus thermophilus to agonist MBP83-99 peptide immunized mouse spleen cells. It was noted that Streptococcus thermophilus induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1 beta and IFN-gamma. Regular consumption of Streptococcus thermophilus may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis.

引用

页数：13

共 55 条

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