SERS-based detection of biomolecules

被引：123
作者：
Cialla, Dana [1 ,2 ,3 ]
Pollok, Sibyll [1 ,2 ,3 ]
Steinbruecker, Carolin [1 ,2 ,3 ]
Weber, Karina [1 ,2 ,3 ]
Popp, Juergen [1 ,2 ,3 ]
机构：
[1] Inst Photon Technol IPHT Jena, D-07745 Jena, Germany
[2] Univ Jena, Inst Phys Chem, D-07743 Jena, Germany
[3] Univ Jena, Abbe Ctr Photon, D-07743 Jena, Germany
来源：
NANOPHOTONICS | 2014年 / 3卷 / 06期
关键词：
biomolecules; Raman; SERS; SURFACE-ENHANCED-RAMAN; LABEL-FREE DETECTION; SINGLE-NUCLEOTIDE POLYMORPHISMS; HIGHLY SENSITIVE DETECTION; ROLLING-CIRCLE AMPLIFICATION; POTENTIAL INDUCED CHANGES; COLLOIDAL SILVER SURFACE; DNA DETECTION; SCATTERING SPECTROSCOPY; CANCER MARKERS;
D O I：
10.1515/nanoph-2013-0024
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In order to detect biomolecules, different approaches using for instance biological, spectroscopic or imaging techniques are established. Due to the broad variety of these methods, this review is focused on surface enhanced Raman spectroscopy (SERS) as an analytical tool in biomolecule detection. Here, the molecular specificity of Raman spectroscopy is combined with metallic nanoparticles as sensor platform, which enhances the signal intensity by several orders of magnitude. Within this article, the characterization of diverse biomolecules by means of SERS is explained and moreover current application fields are presented. The SERS intensity and as a consequence thereof the reliable detection of the biomolecule of interest is effected by distance, orientation and affinity of the molecule towards the metal surface. Furthermore, the great capability of the SERS technique for cutting-edge applications like pathogen detection and cancer diagnosis is highlighted. We wish to motivate by this comprehensive and critical summary researchers from various scientific background to create their own ideas and schemes for a SERS-based detection and analysis of biomolecules.
引用
收藏
页码：383 / 411
页数：29
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