[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells

被引：30

作者：

Lee, Soo-Young ^{[1
]}

Hille, Annegret ^{[2
]}

Kitanovic, Igor ^{[3
]}

Jesse, Patrick ^{[1
]}

Henze, Guenter ^{[1
]}

Woelfl, Stefan ^{[3
]}

Gust, Ronald ^{[2
]}

Prokop, Aram ^{[1
,4
]}

机构：

[1] Univ Med Ctr Charite Berlin, Dept Pediat Oncol Hematol, D-13353 Berlin, Germany

[2] Free Univ Berlin, Inst Pharm, D-1000 Berlin, Germany

[3] Heidelberg Univ, Inst Pharm & Mol Biotechnol, Heidelberg, Germany

[4] Childrens Hosp City Cologne, Dept Pediat Oncol, Cologne, Germany

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 03期

关键词：

Salophene; LDH release; DNA fragmentation; Resistance overcome; Mitochondrial apoptosis; DNA CLEAVAGE; PHOSPHATIDYLSERINE; APOPTOSIS; BINDING;

D O I：

10.1016/j.leukres.2010.11.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We demonstrate the cytotoxic potential of the Schiff base iron complex [Fe-III(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [Fe-III(salophene)Cl] led to the exclusion of unspecific necrosis, a concentration-dependent inhibition of proliferation and a specific apoptotic cell death. We further detected a significant loss of the mitochondrial membrane potential in lymphoma cells and an up-and downregulation of various apoptosis relevant genes, respectively, indicating the involvement of the intrinsic mitochondrial pathway. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：387 / 393

页数：7

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