Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp.

被引：9
|
作者：
Peng, Bo-Rong [1 ,2 ,3 ]
Lai, Kuei-Hung [4 ]
Chen, You-Ying [3 ,5 ]
Su, Jui-Hsin [3 ,6 ]
Huang, Yusheng M. [7 ]
Chen, Yu-Hsin [3 ]
Lu, Mei-Chin [3 ,6 ]
Yu, Steve Sheng-Fa [2 ,8 ]
Duh, Chang-Yih [1 ,5 ]
Sung, Ping-Jyun [3 ,5 ,6 ,9 ,10 ]
机构：
[1] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan
[2] Acad Sinica, Doctoral Degree Program Marine Biotechnol, Taipei 11529, Taiwan
[3] Natl Museum Marine Biol & Aquarium, Pingtung 94450, Taiwan
[4] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 33303, Taiwan
[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan
[6] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan
[7] Natl Penghu Univ Sci & Technol, Dept Marine Recreat, Magong 88046, Penghu, Taiwan
[8] Acad Sinica, Inst Chem, Taipei 11529, Taiwan
[9] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan
[10] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan
来源：
MARINE DRUGS | 2020年 / 18卷 / 02期
关键词：
scalarane; sesterterpenoid; anti-proliferation; Lendenfeldia; BISHOMOSCALARANE SESTERTERPENES; METABOLITES;
D O I：
10.3390/md18020076
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A-D (1- 4), along with three known compounds, 12 alpha-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1-7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1-7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.
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页数：10
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