Synthesis of heterobicyclic nitrogen systems bearing a 1,2,4-triazine moiety as anticancer drugs: Part IV

被引：45

作者：

El-Gendy, Z ^{[1
]}

Morsy, JM ^{[1
]}

Allimony, HA ^{[1
]}

Abdel-Monem, WR ^{[1
]}

Abdel-Rahman, RM ^{[1
]}

机构：

[1] Ain Shams Univ, Dept Chem, Fac Educ, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2003年 / 178卷 / 09期

关键词：

1,2,4-triazines; biological activity; condensed heterocycles;

D O I：

10.1080/10426500390228738

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some new isolated and fused heterobicyclic nitrogen systems such as thiazolidinone, imidazolone, pyrimidinone, quinazolone, as-triazolone, as-triazinones, tetrazino-as-triazines, and the related compounds 3,4-diaminotriazine and sulfa derivatives 2-27 have been synthesized via treatment of 4-amino-6-styryl-3-thioxo-1,2,4-triazin-5(2,4H)ones (1) with cyclic and acyclic oxygen and nitrogen compounds. The structures of the products have been established from their elemental and spectral analyses. Some new compounds exhibited significant anticancer activities, where compounds 11j > 2a > 6 and 11I > 14 > 11k showed a moderate activity toward leukemia, ovarian cancer, and non-small cell lung cancer.

引用

页码：2055 / 2071

页数：17