A Rare Case of HPV-Negative Cervical Squamous Cell Carcinoma

被引：19

作者：

Casey, Shauna ^{[1
]}

Harley, Ian ^{[2
]}

Jamison, Jackie ^{[3
]}

Molijn, Anco ^{[4
]}

van den Munckhof, Henk ^{[4
]}

McCluggage, W. Glenn ^{[1
]}

机构：

[1] Belfast Hlth & Social Care Trust, Dept Pathol, Belfast, Antrim, North Ireland

[2] Belfast Hlth & Social Care Trust, Dept Gynaecol Oncol, Belfast, Antrim, North Ireland

[3] Antrim Area Hosp, Dept Mol Pathol, Belfast, Antrim, North Ireland

[4] DDL Diagnost Lab, Rijswijk, Netherlands

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2015年 / 34卷 / 02期

关键词：

Cervix; Squamous carcinoma; HPV; VULVAR INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS TYPES; FEMALE GENITAL-TRACT; P16; EXPRESSION; LESIONS; ADENOCARCINOMA; OVEREXPRESSION; INFECTION; SPECTRUM; VAGINA;

D O I：

10.1097/PGP.0000000000000132

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.

引用

页码：208 / 212

页数：5

共 50 条

[21] Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas
Kwasniewska, Anna
Postawski, Krzysztof
Gozdzicka-Jozefiak, Anna
Kwasniewski, Wojciech
Grywalska, Ewelina
Zdunek, Malgorzata
Korobowicz, Elzbieta
ONCOLOGY REPORTS, 2011, 26 (01) : 153 - 160
[22] Characterization of DoTc2 4510-Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative
Vuckovic, Nika
Hoppe-Seyler, Karin
Riemer, Angelika B.
CANCERS, 2023, 15 (15)
[23] Immunologic and metabolic characteristics of HPV-negative and HPV-positive head and neck squamous cell carcinomas are strikingly different
Krupar, Rosemarie
Robold, Katharina
Gaag, Doris
Spanier, Gerrit
Kreutz, Marina
Renner, Kathrin
Hellerbrand, Claus
Hofstaedter, Ferdinand
Bosserhoff, Anja K.
VIRCHOWS ARCHIV, 2014, 465 (03) : 299 - 312
[24] Do HPV-negative cervical carcinomas exist? - Revisited
Herrington, CS
JOURNAL OF PATHOLOGY, 1999, 189 (01) : 1 - 3
[25] Long non-coding RNA-OIS1 inhibits HPV-positive, but not HPV-negative cervical squamous cell carcinoma by upregulating MTK-1
Zhou, Dan
Wu, Fengli
Cui, Ying
Wei, Fenghua
Meng, Qingwei
Lv, Qiubo
ONCOLOGY LETTERS, 2019, 17 (03) : 2923 - 2930
[26] NF-B and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma
Gaykalova, Daria A.
Manola, Judith B.
Ozawa, Hiroyuki
Zizkova, Veronika
Morton, Kathryn
Bishop, Justin A.
Sharma, Rajni
Zhang, Chi
Michailidi, Christina
Considine, Michael
Tan, Marietta
Fertig, Elana J.
Hennessey, Patrick T.
Ahn, Julie
Koch, Wayne M.
Westra, William H.
Khan, Zubair
Chung, Christine H.
Ochs, Michael F.
Califano, Joseph A.
INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (08) : 1879 - 1889
[27] Pretreatment Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for the Outcome of HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma
Justesen, Marius Meldgaard
Jakobsen, Kathrine Kronberg
Bendtsen, Simone Kloch
Garset-Zamani, Martin
Mordhorst, Christine
Carlander, Amanda-Louise Fenger
Gothelf, Anita Birgitte
Gronhoj, Christian
von Buchwald, Christian
VIRUSES-BASEL, 2023, 15 (01):
[28] Comparing serum protein levels can aid in differentiating HPV-negative and -positive oropharyngeal squamous cell carcinoma patients
Dickinson, Amy
Saraswat, Mayank
Syrjanen, Stina
Tohmola, Tiialotta
Silen, Robert
Randen-Brady, Reija
Carpen, Timo
Hagstrom, Jaana
Haglund, Caj
Mattila, Petri
Makitie, Antti
Joenvaara, Sakari
Silen, Suvi
PLOS ONE, 2020, 15 (06):
[29] Impact of clinical complete response on treatment outcomes in patients with locally advanced HPV-negative oropharyngeal squamous cell carcinoma
Francesca De Felice
Daniela Musio
Gessica Abate
Erika Moscarelli
Nadia Bulzonetti
Vincenzo Tombolini
Journal of Cancer Research and Clinical Oncology, 2020, 146 : 477 - 483
[30] Impact of clinical complete response on treatment outcomes in patients with locally advanced HPV-negative oropharyngeal squamous cell carcinoma
De Felice, Francesca
Musio, Daniela
Abate, Gessica
Moscarelli, Erika
Bulzonetti, Nadia
Tombolini, Vincenzo
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2020, 146 (02) : 477 - 483

← 1 2 3 4 5 →