A Rare Case of HPV-Negative Cervical Squamous Cell Carcinoma

被引：22

作者：

Casey, Shauna ^{[1
]}

Harley, Ian ^{[2
]}

Jamison, Jackie ^{[3
]}

Molijn, Anco ^{[4
]}

van den Munckhof, Henk ^{[4
]}

McCluggage, W. Glenn ^{[1
]}

机构：

[1] Belfast Hlth & Social Care Trust, Dept Pathol, Belfast, Antrim, North Ireland

[2] Belfast Hlth & Social Care Trust, Dept Gynaecol Oncol, Belfast, Antrim, North Ireland

[3] Antrim Area Hosp, Dept Mol Pathol, Belfast, Antrim, North Ireland

[4] DDL Diagnost Lab, Rijswijk, Netherlands

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2015年 / 34卷 / 02期

关键词：

Cervix; Squamous carcinoma; HPV; VULVAR INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS TYPES; FEMALE GENITAL-TRACT; P16; EXPRESSION; LESIONS; ADENOCARCINOMA; OVEREXPRESSION; INFECTION; SPECTRUM; VAGINA;

D O I：

10.1097/PGP.0000000000000132

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.

引用

页码：208 / 212

页数：5

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