A Rare Case of HPV-Negative Cervical Squamous Cell Carcinoma

被引：19
作者：
Casey, Shauna [1 ]
Harley, Ian [2 ]
Jamison, Jackie [3 ]
Molijn, Anco [4 ]
van den Munckhof, Henk [4 ]
McCluggage, W. Glenn [1 ]
机构：
[1] Belfast Hlth & Social Care Trust, Dept Pathol, Belfast, Antrim, North Ireland
[2] Belfast Hlth & Social Care Trust, Dept Gynaecol Oncol, Belfast, Antrim, North Ireland
[3] Antrim Area Hosp, Dept Mol Pathol, Belfast, Antrim, North Ireland
[4] DDL Diagnost Lab, Rijswijk, Netherlands
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2015年 / 34卷 / 02期
关键词：
Cervix; Squamous carcinoma; HPV; VULVAR INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS TYPES; FEMALE GENITAL-TRACT; P16; EXPRESSION; LESIONS; ADENOCARCINOMA; OVEREXPRESSION; INFECTION; SPECTRUM; VAGINA;
D O I：
10.1097/PGP.0000000000000132
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.
引用
收藏
页码：208 / 212
页数：5
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