The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases

被引：101

作者：

Alijotas-Reig, Jaume ^{[1
,2
]}

Ferrer-Oliveras, Raquel ^{[3
]}

Ruffatti, Amelia ^{[4
]}

Tincani, Angela ^{[5
]}

Lefkou, Elmina ^{[6
]}

Bertero, Ma. Tiziana ^{[7
]}

Coloma-Bazan, Emmanuel ^{[8
]}

de Carolis, Sara ^{[9
]}

Espinosa, Gerard ^{[8
]}

Rovere-Querini, Patrizia ^{[10
,11
]}

Kuzenko, Anna ^{[7
]}

Valverde, Enrique E. ^{[12
]}

Robles, Angel ^{[13
]}

Cervera, Ricard ^{[8
]}

Canti, Valentina ^{[7
]}

Fredi, Micaela ^{[5
]}

Gil-Aguado, Antonio ^{[13
]}

Lundelin, Krista

Llurba, Elisa ^{[3
]}

Melnychuk, Taisiya ^{[3
]}

Nalli, Cecilia ^{[5
]}

Picardo, Elisa ^{[14
]}

Silvestro, Erika ^{[7
]}

del Ross, Teresa ^{[4
]}

Farran-Codina, Inmaculada ^{[3
]}

机构：

[1] Vall dHebron Univ Hosp, Dept Internal Med, Syst Autoimmune Dis Unit, Barcelona, Spain

[2] Univ Autonoma Barcelona, Dept Med, Barcelona 08190, Spain

[3] Univ Autonoma Barcelona, Vall dHebron Univ Hosp, Obstet & Gynaecolgy Dept, Barcelona 08190, Spain

[4] Univ Padua, Azienda Osped, Dept Clin & Expt Med, Rheumatol Unit, Padua, Italy

[5] Osped Civile, Rheumatol & Clin Immunol Unit, Brescia, Italy

[6] Hippokrate Hosp Thessaloniki, Haematoly Unit, Thessaloniki, Greece

[7] AO Mauriziano Umberto I, Dept Clin Immunol, Turin, Italy

[8] Univ Barcelona, Hosp Clin, Syst Autoimmune Dis Serv, Barcelona, Spain

[9] Catholic Univ, Gemmeli Hosp, Dept Gynaecol, Rome, Italy

[10] Vita Salute St Raffaele Univ, Milan, Italy

[11] IRCCS Osped San Raffaele, Milan, Italy

[12] Althaia Healthcare Network Manresa, Dept Internal Med, Barcelona, Spain

[13] Univ Autonoma Madrid, Hosp Univ La Paz, Dept Internal Med, Madrid, Spain

[14] Univ Turin, Dept Obstet & Gynaecol, Turin, Italy

来源：

AUTOIMMUNITY REVIEWS | 2015年 / 14卷 / 05期

关键词：

Antiphospholipid antibody; Laboratory categories; Obstetric antiphospholipid syndrome; Obstetric morbidity; Registry; Treatment; PREGNANCY LOSS; INTERNATIONAL-CONGRESS; LUPUS ANTICOAGULANT; FETAL LOSS; ANTIBODIES; WOMEN; ANTICARDIOLIPIN; PREVALENCE; CRITERIA; DISEASE;

D O I：

10.1016/j.autrev.2014.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To analyse the clinical features, laboratory data, foetal maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS). Methods: The European Registry on APS became a Registry within the framework of the European Forum on Antiphospholipid Antibody projects and placed on a website in June 2010. Cases with obstetric complaints related to aPL who tested positive for aPL prospectively and retrospectively were included. The three-year survey results are reported. Results: 338 women with 1253 pregnancy episodes were included; 915 were historical and 338 were latest episodes. All these women tested positive for aPL. 247 of the 338 fulfilled the Sydney criteria. According to the laboratory categories, 84/247 were in category 1,42 in IIa, 66 in lib and 55 in IIc. Obstetric complications other than foetal losses, appeared in 129 cases (522%). 192 (77.7%) had a live birth and 55 (22.3%) did not. The latter group of only 38 cases (69%) received adequate treatment and 17(31%) did not. 177/247 (72%) women were put on heparin plus LDA. Thrombosis appeared in two during pregnancy and in 14 during the puerperium. 7 (3%) women evolved to complete SLE. Conclusions: OAPS shows differential characteristics than dassicaLAPS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. GAPS has very good foetal maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAFS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：387 / 395

页数：9

共 47 条

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