A chiral chelating diene as a new type of chiral ligand for transition metal catalysts: Its preparation and use for the rhodium-catalyzed asymmetric 1,4-addition

被引：435

作者：

Hayashi, T ^{[1
]}

Ueyama, K ^{[1
]}

Tokunaga, N ^{[1
]}

Yoshida, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 38期

关键词：

D O I：

10.1021/ja037367z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a new type of chiral ligand, a C2-symmetric norbornadiene derivative (1R,4R)-2,5-dibenzylbicyclo[2.2.1]hepta-2,5-diene (1) was prepared and used for the rhodium-catalyzed asymmetric addition of organoboron and -tin reagents to α,β-unsaturated ketones, which gave high yields of the 1,4-addition products with up to 99% enantioselectivity. Copyright © 2003 American Chemical Society.

引用

页码：11508 / 11509

页数：2

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