In order to explore the factors of patients with type 2 diabetic nephropathy (DN), in this paper, 257 patients with type 2 diabetic nephropathy in Zhejiang province were observed, with 156 males and 101 females. The age range was 53-69 years old. According to the ratio of urine albumin/creatinine, it was divided into two groups: the diabetic nephropathy group and the nondiabetic nephropathy group. Age, diabetic course, hypertension, body mass index, glycated hemoglobin, total gallbladder alcohol, high-density lipoprotein, and low-density lipoprotein were compared. The results showed that diabetic diseases, hypertension, HBA1C, and LDL-C were independent risk factors for diabetic nephropathy, and HDL-C was the independent protection factor of DKD (P < 0.05). Therefore, malnutrition and microinflammatory state are the risk causes of the quality of life and survival rate of type 2 diabetic nephropathy MHD patients and actively improve nutritional status. Reducing the status of microinflammatory disease is especially important.