Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women

被引：48

作者：

Singh, Virendra ^{[1
]}

Rastogi, Neeraj ^{[2
]}

Mathur, Neeraj ^{[1
]}

Singh, Kalpana ^{[3
]}

Singh, Mahendra Pratap ^{[1
]}

机构：

[1] Ind Toxicol Res Ctr, Lucknow 226001, Uttar Pradesh, India

[2] Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India

[3] Sarojani Naidu Med Coll, Agra, Uttar Pradesh, India

来源：

ANNALS OF EPIDEMIOLOGY | 2008年 / 18卷 / 01期

关键词：

breast cancer; murine double minute-2; tumor suppressor gene; single nucleotide polymorphism;

D O I：

10.1016/j.annepidem.2007.06.006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

PURPOSE: Single nucleotide polymorphism (SNP) at position -309 (T309G) in MDM-2 promoter induces tumor formation in the individuals possessing inherited p53 mutations. The present study was undertaken to investigate the association of MDM-2 SNP309, p53 Arg72Pro,and p53 intron-6 G/A polymorphism with total, premenopausal, and postmenopausal breast cancer risks in Indian women. METHODS: Genotyping of MDM-2 SNP309, p53 Arg72Pro, and p53 intron-6 G/A in 104 patients and 105 controls was performed either by ARMS-PCR or by polymerase chain reaction and direct sequencing. RESULTS: The p53 Arg72Pro heterozygous variant and in combination with its homozygous variant exhibited a significant protective association with total (odds ratio [95% confidence interval]: 0.42 [0.22-0.81] and 0.46 [0.25-0.85], p value; 0.007 and 0.012) and postmenopausal breast cancer risk (odds ratio [95% confidence interval]: 0.25 [0.07-0.73] and 0.27 [0.08-0.77], p value; 0.009 and 0.013]. Neither combined nor homozygous/heterozygous MDM-2 SNP309G was associated with total, premenopausal, or postmenopausal breast cancer risk; however, MDM-2 SNP309G, along with p53 Arg72Pro heterozygous variant, showed a significant protective association with premenopausal breast cancer risk (odds ratio [95% confidence interval]: 0.18 [0.02-1.20], p value; 0.041 for homozygous + heterozygous MDM-2 SNP309G). CONCLUSIONS: The results indicate protective associations of p53 Arg72Pro heterozygous variant with postmenopausal and MDM-2 SNP309G along with p53 Arg72Pro heterozygous variant with premenopausal breast cancer risk.

引用

页码：48 / 57

页数：10

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