Human Milk and Allergic Diseases: An Unsolved Puzzle

被引：92
作者：
Munblit, Daniel [1 ,2 ,3 ]
Peroni, Diego G. [3 ,4 ]
Boix-Amoros, Alba [3 ,5 ]
Hsu, Peter S. [3 ,6 ]
Van't Land, Belinda [7 ,8 ]
Gay, Melvin C. L. [3 ,9 ]
Kolotilina, Anastasia [2 ]
Skevaki, Chrysanthi [3 ,10 ]
Boyle, Robert J. [1 ,3 ]
Collado, Maria Carmen [3 ,5 ]
Garssen, Johan [7 ,11 ]
Geddes, Donna T. [3 ,9 ]
Nanan, Ralph [12 ]
Slupsky, Carolyn [13 ]
Wegienka, Ganesa [3 ,14 ,15 ]
Kozyrskyj, Anita L. [16 ]
Warner, John O. [1 ,3 ,17 ]
机构：
[1] Imperial Coll London, Dept Paediat, London W2 1NY, England
[2] IM Sechenov First Moscow State Med Univ, Fac Pediat, Moscow 119991, Russia
[3] In FLAME Global Network, West New York, NJ 07093 USA
[4] Univ Pisa, Paediat Sect, Dept Clin & Expt Med, I-56126 Pisa, Italy
[5] Natl Res Council IATA CSIC, Inst Agrochem & Food Technol, Valencia 46980, Spain
[6] Childrens Hosp Westmead, Kids Res Inst, Allergy & Immunol, Sydney, NSW 2145, Australia
[7] Nutricia Res, NL-3584 CT Utrecht, Netherlands
[8] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Paediat Immunol, NL-3584 EA Utrecht, Netherlands
[9] Univ Western Australia, Sch Mol Sci, Perth, WA 6009, Australia
[10] Philipps Univ Marburg, Inst Lab Med & Pathobiochem, Mol Diagnost, Univ Hosp Giessen & Marburg GmbH, Baldingerstr, D-35043 Marburg, Germany
[11] Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, NL-3584 CG Utrecht, Netherlands
[12] Univ Sydney, Charles Perkins Ctr Nepean, Sydney, NSW 2747, Australia
[13] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA
[14] Henry Ford Hlth Syst, Dept Publ Hlth Sci, Detroit, MI 48202 USA
[15] Ctr Urban Responses Environm Stressors, Detroit, MI 48202 USA
[16] Univ Alberta, Dept Pediat, Edmonton, AB T6G 1C9, Canada
[17] Natl Inst Hlth Res, Collaborat Leadership Appl Hlth Res & Care NW Lon, London SW10 9NH, England
来源：
NUTRIENTS | 2017年 / 9卷 / 08期
关键词：
breastfeeding; human milk; allergy; allergic diseases; oligosaccharides; microbiome; cytokines; thymus; GROWTH-FACTOR-BETA; BREAST-FED INFANTS; POLYUNSATURATED FATTY-ACIDS; VITAMIN-D STATUS; SECRETORY IMMUNOGLOBULIN-A; UNMETABOLIZED FOLIC-ACID; PROSPECTIVE BIRTH COHORT; FORMULA-FED INFANTS; 1ST; MONTHS; ATOPIC DISEASE;
D O I：
10.3390/nu9080894
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.
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页数：43
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