Targeting anti-apoptotic BCL-2 family proteins for cancer treatment

被引：23
|
作者：
Zhang, Xuan [1 ]
Liu, Xingui [2 ]
Zhou, Daohong [2 ]
Zheng, Guangrong [1 ]
机构：
[1] Univ Florida, Coll Pharm, Dept Med Chem, 1333 Ctr Dr, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Pharm, Dept Pharmacodynam, 1333 Ctr Dr, Gainesville, FL 32610 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 07期
关键词：
apoptosis; BCL-2; BCL-X-L; cancer treatment; MCL-1; INHIBITOR; POTENT;
D O I：
10.4155/fmc-2020-0004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：563 / 565
页数：3
相关论文
共 50 条
  • [1] Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment
    Zhang, Zhenwei
    Bai, Lijun
    Hou, Linghui
    Deng, Hongguang
    Luan, Shenglin
    Liu, Dan
    Huang, Min
    Zhao, Linxiang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 232
  • [2] Antagonists against anti-apoptotic Bcl-2 family proteins for cancer treatment
    Doshi, Jignesh M.
    Xing, Chengguo
    MINI-REVIEWS IN ORGANIC CHEMISTRY, 2008, 5 (03) : 171 - 178
  • [3] Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy
    O'Neill, J
    Manion, M
    Schwartz, P
    Hockenbery, DM
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2004, 1705 (01): : 43 - 51
  • [4] Patent landscape of inhibitors and PROTACs of the anti-apoptotic BCL-2 family proteins
    Pal, Pratik
    Zhang, Peiyi
    Poddar, Saikat K.
    Zheng, Guangrong
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2022, 32 (09) : 1003 - 1026
  • [5] Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
    Inoue-Yamauchi, Akane
    Jeng, Paul S.
    Kim, Kwanghee
    Chen, Hui-Chen
    Han, Song
    Ganesan, Yogesh Tengarai
    Ishizawa, Kota
    Jebiwott, Sylvia
    Dong, Yiyu
    Pietanza, Maria C.
    Hellmann, Matthew D.
    Kris, Mark G.
    Hsieh, James J.
    Cheng, Emily H.
    NATURE COMMUNICATIONS, 2017, 8
  • [6] Anti-apoptotic BCL-2 family proteins in acute neural injury
    Anilkumar, Ujval
    Prehn, Jochen H. M.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2014, 8
  • [7] Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: New avenues for cancer chemoprevention and chemotherapy
    Pellecchia, M
    Reed, JC
    CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (12) : 1387 - 1398
  • [8] Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival
    Eichhorn, Joshua M.
    Alford, Sarah E.
    Sakurikar, Nandini
    Chambers, Timothy C.
    EXPERIMENTAL CELL RESEARCH, 2014, 322 (02) : 415 - 424
  • [9] Rise of the Selective Inhibitors of Anti-Apoptotic Bcl-2 Family Proteins
    Han, Li
    Wang, Renxiao
    CHEMMEDCHEM, 2013, 8 (09) : 1437 - 1440
  • [10] Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules
    Valentini, Elisabetta
    D'Aguanno, Simona
    Di Martile, Marta
    Montesano, Camilla
    Ferraresi, Virginia
    Patsilinakos, Alexandros
    Sabatino, Manuela
    Antonini, Lorenzo
    Chiacchiarini, Martina
    Valente, Sergio
    Mai, Antonello
    Colotti, Gianni
    Ragno, Rino
    Trisciuoglio, Daniela
    Del Bufalo, Donatella
    THERANOSTICS, 2022, 12 (05): : 2427 - 2444
12345