Differentiation of Vein and Lymphatic Vessel by Photoacoustic Imaging System with Parabolic Array Transducer and Tunable Laser

被引:0
作者
Tabata, Takuya [1 ]
Nagaoka, Ryo [1 ]
Umemura, ShinIchiro [1 ]
Saijo, Yoshifumi [1 ]
Yoshizawa, Shin [2 ]
机构
[1] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi, Japan
[2] Tohoku Univ, Grad Sch Engn, Sendai, Miyagi, Japan
来源
2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) | 2017年
基金
日本学术振兴会;
关键词
photoacoustic imaging; lymphatic vessel; tunable laser; gold nanorod; ULTRASOUND; NANO/MICROBUBBLES; METASTASIS; DELIVERY; NODE;
D O I
暂无
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Recently, much attention is being paid to lymphatic circulation because intralymphatic immunotherapy and chemotherapy achieved significant clinical benefits. However, conventional ultrasound or photoacoustic (PA) imaging is hard to visualize lymphatic vessels. In the present study, real-time threedimensional PA imaging system consisted of 256-ch parabolic array transducer with the central frequency of 10 MHz and tunable laser with the wavelength of 400-2100 nm was developed. Photoacoustic contrast agents such indocyanine green (ICG) or gold nanorods (AuNRs) were administrated to the lymphatic vessels of the ICR mouse. The vein was visualized at the wavelength of 490-600 nm without contrast agents. The lymphatic vessel was visualized at 670-770 nm with ICG and at 790-890 nm with AuNRs. The system is clinically applicable for detection of small lymphatic vessels to confirm successful drug delivery during intralymphatic chemotherapy.
引用
收藏
页数:4
相关论文
共 7 条
[1]   A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound [J].
Kato, Shigeki ;
Mori, Shiro ;
Kodama, Tetsuya .
JOURNAL OF CANCER, 2015, 6 (12) :1282-1294
[2]   DELIVERY OF MOLECULES TO THE LYMPH NODE VIA LYMPHATIC VESSELS USING ULTRASOUND AND NANO/MICROBUBBLES [J].
Kato, Shigeki ;
Shirai, Yuko ;
Kanzaki, Hiroyuki ;
Sakamoto, Maya ;
Mori, Shiro ;
Kodama, Tetsuya .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2015, 41 (05) :1411-1421
[3]   New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network [J].
Kodama, Tetsuya ;
Matsuki, Daisuke ;
Tada, Asuka ;
Takeda, Kazu ;
Mori, Shiro .
SCIENTIFIC REPORTS, 2016, 6
[4]   Metastasis: a question of life or death [J].
Mehlen, P ;
Puisieux, A .
NATURE REVIEWS CANCER, 2006, 6 (06) :449-458
[5]   Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer [J].
Nagaoka, Ryo ;
Tabata, Takuya ;
Takagi, Ryo ;
Yoshizawa, Shin ;
Umemura, Shin-Ichiro ;
Saijo, Yoshifumi .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2017, 64 (08) :1223-1233
[6]   THE COMBINATION OF INTRALYMPHATIC CHEMOTHERAPY WITH ULTRASOUND AND NANO-/MICROBUBBLES IS EFFICIENT IN THE TREATMENT OF EXPERIMENTAL TUMORS IN MOUSE LYMPH NODES [J].
Sato, Takuma ;
Mori, Shiro ;
Arai, Yoichi ;
Kodama, Tetsuya .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2014, 40 (06) :1237-1249
[7]  
Yamamoto H., 2016, CLIN CANC RES