N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer

被引：9

作者：

Ge, Yiling ^{[1
]}

Liu, Tong ^{[1
]}

Wang, Chuntao ^{[2
]}

Zhang, Yanqiu ^{[3
]}

Xu, Siyi ^{[1
]}

Ren, Yiyi ^{[1
]}

Feng, Yanlu ^{[1
]}

Yin, Lihong ^{[1
]}

Pu, Yuepu ^{[1
]}

Liang, Geyu ^{[1
]}

机构：

[1] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Jiangsu, Peoples R China

[2] Jiangsu Vocat Coll Med, Sci & Technol Dept, Yancheng, Jiangsu, Peoples R China

[3] Taizhou Ctr Dis Control & Prevent, Dept Environm Occupat Hlth, Taizhou, Peoples R China

来源：

RNA BIOLOGY | 2021年 / 18卷

基金：

中国国家自然科学基金;

关键词：

N6-methyladenosine (m6A); colorectal cancer (CRC); non-coding rnas (ncRNAs); cancer progression; RNA modification; MESSENGER-RNA; M(6)A METHYLTRANSFERASE; N-6-METHYLADENOSINE M(6)A; NUCLEAR-RNA; METHYLATION; METTL3; M6A; DIFFERENTIATION; PROLIFERATION; DEMETHYLATION;

D O I：

10.1080/15476286.2021.1974749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As one of the most common forms of RNA modification, N6-methyladenosine (m6A) RNA modification has attracted increasing research interest in recent years. This reversible RNA modification added a new dimension to the post-transcriptional regulation of gene expression. In colorectal cancer (CRC), the role of m6A modification has been extensively studied, not only on mRNAs but also on non-coding RNAs (ncRNAs). In the present review, we depicted the role of m6A modification in CRC, systematically elaborate the interaction between m6A modification and regulatory ncRNAs in function and mechanism. Moreover, we discussed the potential applications in clinical.

引用

页码：551 / 561

页数：11

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