Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes?

被引：34

作者：

Kosmider, Olivier ^{[1
]}

Passet, Marie ^{[1
]}

Santini, Valeria ^{[2
]}

Platzbecker, Uwe ^{[3
]}

Andrieu, Valerie ^{[4
]}

Zini, Gina ^{[5
]}

Beyne-Rauzy, Odile ^{[6
]}

Guerci, Agnes ^{[7
]}

Masala, Erico ^{[8
]}

Balleari, Enrico ^{[9
]}

Bulycheva, Ekaterina ^{[3
]}

Dreyfus, Francois ^{[10
]}

Fenaux, Pierre ^{[11
]}

Fontenay, Michaela ^{[1
]}

Park, Sophie ^{[12
]}

机构：

[1] Hop Cochin, AP HP, Hematol Biol, Paris, France

[2] Univ Florence, AOU Careggi, Hematol, I-50121 Florence, Italy

[3] Univ Hosp Carl Gustav Dresden, Dresden, Germany

[4] Hop Bichat Claude Bernard, AP HP, Hematol Biol, Paris, France

[5] Univ Cattolica Sacro Cuore, Rome, Italy

[6] Oncopole, IUCT, Toulouse, France

[7] Hop Brabois, Nancy, France

[8] Univ Florence, Florence, Italy

[9] IRCCS AOU San Martino IST Genova, Genoa, Italy

[10] Hop Cochin, Serv Hematol, Paris, France

[11] Hop St Louis, Serv Hematol Seniors, Paris, France

[12] Univ Grenoble Alpes, CHU Grenoble Alpes, Clin Univ Hematol, Grenoble, France

来源：

HAEMATOLOGICA | 2016年 / 101卷 / 07期

关键词：

myelodysplastic syndromes; cytogenetics and molecular genetics; red cells; SURVIVAL; IMPACT; MODEL;

D O I：

10.3324/haematol.2016.142695

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：280 / 283

页数：4

共 14 条

[1] Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation [J].

Bejar, Rafael ;

Stevenson, Kristen E. ;

Caughey, Bennett ;

Lindsley, R. Coleman ;

Mar, Brenton G. ;

Stojanov, Petar ;

Getz, Gad ;

Steensma, David P. ;

Ritz, Jerome ;

Soiffer, Robert ;

Antin, Joseph H. ;

Alyea, Edwin ;

Armand, Philippe ;

Ho, Vincent ;

Koreth, John ;

Neuberg, Donna ;

Cutler, Corey S. ;

Ebert, Benjamin L. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (25) :2691-+

[2] Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes [J].

Bejar, Rafael ;

Stevenson, Kristen E. ;

Caughey, Bennett A. ;

Abdel-Wahab, Omar ;

Steensma, David P. ;

Galili, Naomi ;

Raza, Azra ;

Kantarjian, Hagop ;

Levine, Ross L. ;

Neuberg, Donna ;

Garcia-Manero, Guillermo ;

Ebert, Benjamin L. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (27) :3376-3382

[3] p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes [J].

Frisan, Emilie ;

Pawlikowska, Patrycja ;

Pierre-Eugene, Cecile ;

Viallon, Vivian ;

Gibault, Laure ;

Park, Sophie ;

Mayeux, Patrick ;

Dreyfus, Francois ;

Porteu, Francoise ;

Fontenay, Michaela .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (11) :1964-1968

[4] Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996) [J].

Greenberg, Peter L. ;

Sun, Zhuoxin ;

Miller, Kenneth B. ;

Bennett, John M. ;

Tallman, Martin S. ;

Dewald, Gordon ;

Paietta, Elisabeth ;

van der Jagt, Richard ;

Houston, Jessie ;

Thomas, Mary L. ;

Cella, David ;

Rowe, Jacob M. .

BLOOD, 2009, 114 (12) :2393-2400

[5] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes [J].

Haferlach, T. ;

Nagata, Y. ;

Grossmann, V. ;

Okuno, Y. ;

Bacher, U. ;

Nagae, G. ;

Schnittger, S. ;

Sanada, M. ;

Kon, A. ;

Alpermann, T. ;

Yoshida, K. ;

Roller, A. ;

Nadarajah, N. ;

Shiraishi, Y. ;

Shiozawa, Y. ;

Chiba, K. ;

Tanaka, H. ;

Koeffler, H. P. ;

Klein, H-U ;

Dugas, M. ;

Aburatani, H. ;

Kohlmann, A. ;

Miyano, S. ;

Haferlach, C. ;

Kern, W. ;

Ogawa, S. .

LEUKEMIA, 2014, 28 (02) :241-247

[6] A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin plus granulocyte colony-stimulating factor:: significant effects on quality of life [J].

Hellström-Lindberg, E ;

Gulbrandsen, N ;

Lindberg, G ;

Ahlgren, T ;

Dahl, IMS ;

Dybedal, I ;

Grimfors, G ;

Hesse-Sundin, E ;

Hjorth, M ;

Kanter-Lewensohn, L ;

Linder, O ;

Luthman, M ;

Löfvenberg, E ;

Öberg, G ;

Porwit-MacDonald, A ;

Rådlund, A ;

Samuelsson, J ;

Tangen, JM ;

Winquist, I ;

Wisloff, F .

BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (06) :1037-1046

[7] Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias [J].

Itzykson, R. ;

Kosmider, O. ;

Cluzeau, T. ;

Mansat-De Mas, V. ;

Dreyfus, F. ;

Beyne-Rauzy, O. ;

Quesnel, B. ;

Vey, N. ;

Gelsi-Boyer, V. ;

Raynaud, S. ;

Preudhomme, C. ;

Ades, L. ;

Fenaux, P. ;

Fontenay, M. .

LEUKEMIA, 2011, 25 (07) :1147-1152

[8] Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic syndrome [J].

Jadersten, Martin ;

Malcovati, Luca ;

Dybedal, Ingunn ;

Della Porta, Matteo Giovanni ;

Invernizzi, Rosangela ;

Montgomery, Scott M. ;

Pascutto, Cristiana ;

Porwit, Anna ;

Cazzola, Mario ;

Hellstrom-Lindberg, Eva .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (21) :3607-3613

[9] Clinical and biological implications of driver mutations in myelodysplastic syndromes [J].

Papaemmanuil, Elli ;

Gerstung, Moritz ;

Malcovati, Luca ;

Tauro, Sudhir ;

Gundem, Gunes ;

Van Loo, Peter ;

Yoon, Chris J. ;

Ellis, Peter ;

Wedge, David C. ;

Pellagatti, Andrea ;

Shlien, Adam ;

Groves, Michael John ;

Forbes, Simon A. ;

Raine, Keiran ;

Hinton, Jon ;

Mudie, Laura J. ;

McLaren, Stuart ;

Hardy, Claire ;

Latimer, Calli ;

Della Porta, Matteo G. ;

O'Meara, Sarah ;

Ambaglio, Ilaria ;

Galli, Anna ;

Butler, Adam P. ;

Walldin, Gunilla ;

Teague, Jon W. ;

Quek, Lynn ;

Sternberg, Alex ;

Gambacorti-Passerini, Carlo ;

Cross, Nicholas C. P. ;

Green, Anthony R. ;

Boultwood, Jacqueline ;

Vyas, Paresh ;

Hellstrom-Lindberg, Eva ;

Bowen, David ;

Cazzola, Mario ;

Stratton, Michael R. ;

Campbell, Peter J. .

BLOOD, 2013, 122 (22) :3616-3627

[10] Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF:: the GFM experience [J].

Park, Sophie ;

Grabar, Sophie ;

Kelaidi, Charikleia ;

Beyne-Rauzy, Odile ;

Picard, Francoise ;

Bardet, Valerie ;

Coiteux, Valerie ;

Leroux, Genevieve ;

Lepelley, Pascale ;

Daniel, Marie-Therese ;

Cheze, Stephane ;

Mahe, Beatrice ;

Ferrant, Augustin ;

Ravoet, Christophe ;

Escoffre-Barbe, Martine ;

Ades, Lionel ;

Vey, Norbert ;

Aljassern, Lina ;

Stamatoullas, Aspasia ;

Mannone, Lionel ;

Dombret, Herve ;

Bourgeois, Keith ;

Greenberg, Peter ;

Fenaux, Pierre ;

Dreyfus, Francois .

BLOOD, 2008, 111 (02) :574-582

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