Efficacy of levamisole on experimental endometriosis

被引：14

作者：

Ocal, G.

Kokcu, A.

Cetinkaya, M. B.

Tosun, M.

Kefeli, M.

Kandemir, B.

机构：

[1] Ondokuz Mayis Univ, Sch Med, Dept Obstet & Gynecol, Samsun, Turkey

[2] Ondokuz Mayis Univ, Sch Med, Dept Pathol, Samsun, Turkey

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2007年 / 99卷 / 01期

关键词：

endometriosis; levamisole; leuprolide; medroxyprogesterone acetate;

D O I：

10.1016/j.ijgo.2007.04.041

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate the efficacy of levamisole on experimental endometriosis. Methods: After the implantation of endometrial tissue on abdominal peritoneum, 40 rats were randomized to 1 of 4 equal intervention groups. Levamisole (2 mg/rat) was applied subcutaneously to group "L" once a week. Depot medroxyprogesterone acetate (3 mg/kg) was applied intramuscularly to group "M" twice at 4-week intervals. Leuprolide (0.075 mg/kg) was applied subcutaneously to group "G" twice at 4-week intervals. Saline (0.1 cm(3)/rat) was applied subcutaneously to group "C" once a week for 8 weeks. The efficacy of levamisole was determined by volume measurement and characterizing the histological structure of the implants. Result: Volume increase of the implants in group C (P<0.05), and volume decrease in groups M, G, and L was found (P<0.05, P<0.01, and P<0.01, respectively.) Stromal tissue and glandular activity were not different between groups L and G. Conclusion: Levamisole was found to be as effective as leuprolide in regression of the volume of endometriotic implants. (C) 2007 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：38 / 42

页数：5

共 26 条

[1] Use of intraperitoneal interferon α-2b therapy after conservative surgery for endometriosis and postoperative medical treatment with depot gonadotropin-releasing hormone analog:: a randomized clinical trial [J].