Limited effectiveness for the therapeutic blockade of interferon α in systemic lupus erythematosus: a possible role for type III interferons Type III interferons in lupus

被引：24
作者：
Amezcua-Guerra, Luis M. [1 ,2 ,3 ]
Ferrusquia-Toriz, Diana [1 ]
Castillo-Martinez, Diana [4 ]
Marquez-Velasco, Ricardo [1 ]
Karina Chavez-Rueda, Adriana [5 ]
Bojalil, Rafael [1 ,3 ]
机构：
[1] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Mexico City, DF, Mexico
[2] Univ Autonoma Metropolitana Xochimilco, Biol & Hlth Sci, Mexico City, DF, Mexico
[3] Univ Autonoma Metropolitana Xochimilco, Dept Hlth Care, Mexico City, DF, Mexico
[4] Hosp Gen Zona 1A Dr Rodolfo Antonio de Mucha Maci, Dept Dermatol, Mexico City, DF, Mexico
[5] Inst Mexicano Seguro Social, Immunol Unit, Hosp Pediat, CMN Siglo 21, Mexico City, DF, Mexico
来源：
RHEUMATOLOGY | 2015年 / 54卷 / 02期
关键词：
MONOCLONAL-ANTIBODY; PHASE-I; SIFALIMUMAB; EXPRESSION; BLOOD;
D O I：
10.1093/rheumatology/keu020
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：203 / 205
页数：3
相关论文
共 10 条
[1]   Interferon and granulopoiesis signatures in systemic lupus erythematosus blood [J].
Bennett, L ;
Palucka, AK ;
Arce, E ;
Cantrell, V ;
Borvak, J ;
Banchereau, J ;
Pascual, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :711-723
[2]   Interferon-Lambda: A New Addition to an Old Family [J].
Donnelly, Raymond P. ;
Kotenko, Sergei V. .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (08) :555-564
[3]   Mechanisms of Type III Interferon Expression [J].
Iversen, Marie B. ;
Paludan, Soren R. .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (08) :573-578
[4]   Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF-κB than Type I IFNs [J].
Iversen, Marie B. ;
Ank, Nina ;
Melchjorsen, Jesper ;
Paludan, Soren R. .
JOURNAL OF VIROLOGY, 2010, 84 (09) :4579-4586
[5]   Emerging therapies for systemic lupus erythematosus - Focus on targeting interferon-alpha [J].
Lichtman, Eben I. ;
Helfgott, Simon M. ;
Kriegel, Martin A. .
CLINICAL IMMUNOLOGY, 2012, 143 (03) :210-221
[6]   Profiling the expression of interleukin (IL)-28 and IL-28 receptor α in systemic lupus erythematosus patients [J].
Lin, Shih-Chang ;
Kuo, Chia-Chen ;
Tsao, Jeng-Ting ;
Lin, Li-Jing .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2012, 42 (01) :61-69
[7]   Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study [J].
Merrill, Joan T. ;
Wallace, Daniel J. ;
Petri, Michelle ;
Kirou, Kyriakos A. ;
Yao, Yihong ;
White, Wendy I. ;
Robbie, Gabriel ;
Levin, Robert ;
Berney, Seth M. ;
Chindalore, Vishala ;
Olsen, Nancy ;
Richman, Laura ;
Le, Chenxiong ;
Jallal, Bahija ;
White, Barbara .
ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (11) :1905-1913
[8]   Sifalimumab, a Human AntiInterferon- Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study [J].
Petri, Michelle ;
Wallace, Daniel J. ;
Spindler, Alberto ;
Chindalore, Vishala ;
Kalunian, Kenneth ;
Mysler, Eduardo ;
Neuwelt, C. Michael ;
Robbie, Gabriel ;
White, Wendy I. ;
Higgs, Brandon W. ;
Yao, Yihong ;
Wang, Liangwei ;
Ethgen, Dominique ;
Greth, Warren .
ARTHRITIS AND RHEUMATISM, 2013, 65 (04) :1011-1021
[9]   IFN-lambda (IFN-λ) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo [J].
Sommereyns, Caroline ;
Paul, Sophie ;
Staeheli, Peter ;
Michiels, Thomas .
PLOS PATHOGENS, 2008, 4 (03)
[10]   Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity [J].
Wu, Qian ;
Yang, Qingrui ;
Lourenco, Elaine ;
Sun, Hongsheng ;
Zhang, Yuanchao .
ARTHRITIS RESEARCH & THERAPY, 2011, 13 (03)
1