Management of perianal fistulas in Crohn's disease: An up-to-date review

被引：66
作者：
Marzo, Manuela [1 ]
Felice, Carla [1 ]
Pugliese, Daniela [1 ]
Andrisani, Gianluca [1 ]
Mocci, Giammarco [1 ]
Armuzzi, Alessandro [1 ]
Guidi, Luisa [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, IBD Unit, Complesso Integrato Columbus, I-00168 Rome, Italy
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 05期
关键词：
Crohn's disease; Perianal fistula; Surgery; Drug therapy; Tumor necrosis factor alpha; INFLAMMATORY-BOWEL-DISEASE; INFLIXIMAB MAINTENANCE THERAPY; RANDOMIZED CLINICAL-TRIAL; COMBINED SETON PLACEMENT; COMPLEX ANAL FISTULA; FIBRIN GLUE; ANORECTAL FISTULAS; HYDROGEN-PEROXIDE; LOCAL INJECTION; IN-ANO;
D O I：
10.3748/wjg.v21.i5.1394
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Perianal disease is one of the most disabling manifestations of Crohn's disease. A multidisciplinary approach of gastroenterologist, colorectal surgeon and radiologist is necessary for its management. A correct diagnosis, based on endoscopy, magnetic resonance imaging, endoanal ultrasound and examination under anesthesia, is crucial for perianal fistula treatment. Available medical and surgical therapies are discussed in this review, including new local treatment modalities that are under investigation.
引用
收藏
页码：1394 / 1403
页数：10
相关论文
共 88 条
[71]   Randomised clinical trial: certolizumab pegol for fistulas in Crohn's disease - subgroup results from a placebo-controlled study [J].
Schreiber, S. ;
Lawrance, I. C. ;
Thomsen, O. O. ;
Hanauer, S. B. ;
Bloomfield, R. ;
Sandborn, W. J. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 33 (02) :185-193
[72]   The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota [J].
Schwartz, DA ;
Loftus, EV ;
Tremaine, WJ ;
Panaccione, R ;
Harmsen, WS ;
Zinsmeister, AR ;
Sandborn, WJ .
GASTROENTEROLOGY, 2002, 122 (04) :875-880
[73]   A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas [J].
Schwartz, DA ;
Wiersema, MJ ;
Dudiak, KM ;
Fletcher, JG ;
Clain, JE ;
Tremaine, WJ ;
Zinsmeister, AR ;
Norton, ID ;
Boardman, LA ;
Devine, RM ;
Wolff, BG ;
Young-Fadok, TM ;
Diehl, NN ;
Pemberton, JH ;
Sandborn, WJ .
GASTROENTEROLOGY, 2001, 121 (05) :1064-1072
[74]   A Diagnostic Accuracy Meta-analysis of Endoanal Ultrasound and MRI for Perianal Fistula Assessment [J].
Siddiqui, Muhammed R. S. ;
Ashrafian, Hutan ;
Tozer, Phil ;
Daulatzai, Najib ;
Burling, David ;
Hart, Ailsa ;
Athanasiou, Thanos ;
Phillips, Robin K. .
DISEASES OF THE COLON & RECTUM, 2012, 55 (05) :576-585
[75]   Endorectal Advancement Flap for Cryptoglandular or Crohn's Fistula-in-Ano [J].
Soltani, Ali ;
Kaiser, Andreas M. .
DISEASES OF THE COLON & RECTUM, 2010, 53 (04) :486-495
[76]   Infliximab in the surgical management of complex fistulating anal Crohn's disease [J].
Talbot, C ;
Sagar, PM ;
Johnston, MJ ;
Finan, PJ ;
Burke, D .
COLORECTAL DISEASE, 2005, 7 (02) :164-168
[77]  
Tanaka S, 2010, HEPATO-GASTROENTEROL, V57, P3
[78]   Ciprofloxacin or Metronidazole for the Treatment of Perianal Fistulas in Patients with Crohn's Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study [J].
Thia, Kelvin T. ;
Mahadevan, Uma ;
Feagan, Brian G. ;
Wong, Cindy ;
Cockeram, Alan ;
Bitton, Alain ;
Bernstein, Charles N. ;
Sandborn, William J. .
INFLAMMATORY BOWEL DISEASES, 2009, 15 (01) :17-24
[79]   Effectiveness and Safety of Local Adalimumab Injection in Patients With Fistulizing Perianal Crohn's Disease: A Pilot Study [J].
Tonelli, Francesco ;
Giudici, Francesco ;
Asteria, Corrado Rosario .
DISEASES OF THE COLON & RECTUM, 2012, 55 (08) :870-875
[80]   Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn's disease - A single center experience [J].
Topstad, DR ;
Panaccione, R ;
Heine, JA ;
Johnson, DRE ;
MacLean, AR ;
Buie, WD .
DISEASES OF THE COLON & RECTUM, 2003, 46 (05) :577-583
123456789