Melanization immune responses in mosquito vectors

被引：290
作者：
Christensen, BM
Li, JY
Chen, CC
Nappi, AJ
机构：
[1] Univ Wisconsin, Dept Anim Hlth & Biomed Sci, Madison, WI 53706 USA
[2] Univ Illinois, Dept Pathol Sci, Urbana, IL 61801 USA
[3] Natl Yang Ming Univ, Dept Parasitol, Taipei 112, Taiwan
来源：
TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 04期
关键词：
D O I：
10.1016/j.pt.2005.02.007
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The production and deposition of melanin pigments on invading pathogens and parasites represents a unique, innate immune response in the phylum Arthropoda. This immune response has started to receive considerable attention because of the potential to exploit this mechanism to control mosquito-borne diseases. In this article, we summarize knowledge about this complex biochemistry, the use of melanin biosynthesis in diverse physiological processes and the gaps in knowledge that must be addressed if this immune process is to be manipulated in genetic-based control strategies.
引用
收藏
页码：192 / 199
页数：8
相关论文
共 67 条
[1]   Genomic structure and ecdysone regulation of the prophenoloxidase 1 gene in the malaria vector Anopheles gambiae [J].
Ahmed, A ;
Martin, D ;
Manetti, AGO ;
Han, SJ ;
Lee, WJ ;
Mathiopoulos, KD ;
Müller, HM ;
Kafatos, FC ;
Raikhel, A ;
Brey, PT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14795-14800
[2]   Isoform-dependent phenol oxidase activity during the developmental stages in Drosophila melanogaster [J].
Asada, N .
BIOCHEMICAL GENETICS, 2003, 41 (7-8) :263-268
[3]   Description of the transcriptomes of immune response-activated Hemocytes from the mosquito vectors Aedes aegypti and Armigeres subalbatus [J].
Bartholomay, LC ;
Cho, WL ;
Rocheleau, TA ;
Boyle, JP ;
Beck, ET ;
Fuchs, JF ;
Liss, P ;
Rusch, M ;
Butler, KM ;
Wu, RCC ;
Lin, SP ;
Kuo, FY ;
Tsao, IY ;
Huang, CY ;
Liu, TT ;
Hsiao, KJ ;
Tsai, SF ;
Yang, UC ;
Nappi, AJ ;
Perna, NT ;
Chen, CC ;
Christensen, BM .
INFECTION AND IMMUNITY, 2004, 72 (07) :4114-4126
[4]   Thioredoxin reductase from the malaria mosquito Anopheles gambiae -: Comparisons with the orthologous enzymes of Plasmodium falciparum and the human host [J].
Bauer, H ;
Gromer, S ;
Urbani, A ;
Schnölzer, M ;
Schirmer, RH ;
Müller, HM .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (21) :4272-4281
[5]   Genetics of mosquito vector competence [J].
Beerntsen, BT ;
James, AA ;
Christensen, BM .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (01) :115-+
[6]   Innate immunity: an overview [J].
Beutler, B .
MOLECULAR IMMUNOLOGY, 2004, 40 (12) :845-859
[7]   Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae [J].
Blandin, S ;
Shiao, SH ;
Moita, LF ;
Janse, CJ ;
Waters, AP ;
Kafatos, FC ;
Levashina, EA .
CELL, 2004, 116 (05) :661-670
[8]   Direct and indirect immunosuppression by a malaria parasite in its mosquito vector [J].
Boëte, C ;
Paul, REL ;
Koella, JC .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2004, 271 (1548) :1611-1615
[9]   Reduced efficacy of the immune melanization response in mosquitoes infected by malaria parasites [J].
Boëte, C ;
Paul, REL ;
Koella, JC .
PARASITOLOGY, 2002, 125 :93-98
[10]   The prophenoloxidase-activating system in invertebrates [J].
Cerenius, L ;
Söderhäll, K .
IMMUNOLOGICAL REVIEWS, 2004, 198 :116-126
1234567