Comparison of ambulatory blood pressure-lowering effects of higher doses of different calcium antagonists in uncontrolled hypertension: the Calcium Antagonist Controlled-Release High-Dose Therapy in Uncontrolled Refractory Hypertensive Patients (CARILLON) Study

被引：6
作者：
Mizuno, Hiroyuki [1 ]
Hoshide, Satoshi [1 ]
Tomitani, Naoko [1 ]
Kario, Kazuomi [1 ]
机构：
[1] Jichi Med Univ, Sch Med, Dept Med, Div Cardiovasc Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan
来源：
BLOOD PRESSURE | 2017年 / 26卷 / 05期
关键词：
High-dose calcium antagonist; nifedipine controlled-release; amlodipine; ambulatory blood pressure; morning blood pressure surge; urinary albumin creatinine ratio; renal protection; URINARY ALBUMIN EXCRETION; COMBINATION THERAPY; NATRIURETIC PEPTIDE; TROPONIN-T; NIFEDIPINE; RISK; AMLODIPINE; SAFETY;
D O I：
10.1080/08037051.2017.1329623
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Background: Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. This was a prospective, randomized, multicenter, open-label trial.Patients and methods: Fifty-one uncontrolled hypertensives medicated by two or more antihypertensive drugs including a renin-angiotensin system inhibitor and a calcium antagonist were randomly assigned to either the nifedipine CR (80mg)/candesartan (8mg) group or the amlodipine (10mg)/candesartan (8mg) group.Results: The changes in 24-hr BP were comparable between the groups. The nifedipine group demonstrated a significant decrease in their urinary albumin creatinine ratio, whereas the amlodipine group demonstrated a significant decrease in their NTproBNP level. However, there was no significant difference in any biomarkers between the two groups.Conclusion: Nifedipine showed an almost equal effect on ambulatory blood pressure as amlodipine. Their potentially differential effects on renal protection and NTproBNP should be tested in larger samples.
引用
收藏
页码：284 / 293
页数：10
相关论文
共 20 条
[1]   Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J].
Brenner, BM ;
Cooper, ME ;
de Zeeuw, D ;
Keane, WF ;
Mitch, WE ;
Parving, HH ;
Remuzzi, G ;
Snapinn, SM ;
Zhang, ZX ;
Shahinfar, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) :861-869
[2]   Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population [J].
de Lemos, James A. ;
Drazner, Mark H. ;
Omland, Torbjorn ;
Ayers, Colby R. ;
Khera, Amit ;
Rohatgi, Anand ;
Hashim, Ibrahim ;
Berry, Jarett D. ;
Das, Sandeep R. ;
Morrow, David A. ;
McGuire, Darren K. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (22) :2503-2512
[3]   Troponin T, N-Terminal Pro-B-Type Natriuretic Peptide, and Incidence of Stroke The Atherosclerosis Risk in Communities Study [J].
Folsom, Aaron R. ;
Nambi, Vijay ;
Bell, Elizabeth J. ;
Oluleye, Oludamilola W. ;
Gottesman, Rebecca F. ;
Lutsey, Pamela L. ;
Huxley, Rachel R. ;
Ballantyne, Christie M. .
STROKE, 2013, 44 (04) :961-+
[4]   Differential effects of strict blood pressure lowering by losartan/hydrochlorothiazide combination therapy and high-dose amlodipine monotherapy on microalbuminuria: the ALPHABET study [J].
Fukutomi, Motoki ;
Hoshide, Satoshi ;
Eguchi, Kazuo ;
Watanabe, Tomonori ;
Shimada, Kazuyuki ;
Kario, Kazuomi .
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2012, 6 (01) :73-82
[5]   Controlled-release nifedipine and candesartan low-dose combination therapy in patients with essential hypertension: the NICE Combi (Nifedipine and Candesartan Combination) Study [J].
Hasebe, N ;
Kikuchi, K .
JOURNAL OF HYPERTENSION, 2005, 23 (02) :445-453
[6]   Difference between home and office blood pressures among treated hypertensive patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study [J].
Horikawa, Tsuyoshi ;
Obara, Taku ;
Ohkubo, Takayoshi ;
Metoki, Hirohito ;
Inoue, Ryusuke ;
Kikuya, Masahiro ;
Hashimoto, Junichiro ;
Totsune, Kazuhito ;
Imai, Yutaka .
HYPERTENSION RESEARCH, 2008, 31 (06) :1115-1123
[7]   Determinants of exaggerated difference in morning and evening blood pressure measured by self-measured blood pressure monitoring in medicated hypertensive patients: Jichi Morning Hypertension Research (J-MORE) study [J].
Ishikawa, J ;
Kario, K ;
Hoshide, S ;
Eguchi, K ;
Morinari, M ;
Kaneda, R ;
Umeda, Y ;
Ishikawa, S ;
Kuroda, T ;
Hojo, Y ;
Shimada, K .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (07) :958-965
[8]   Assessment on Antihypertensive Effect and Safety of Nifedipine Controlled-Release Tablet Administered at 80 mg/day in Practical Clinic [J].
Kobayashi, Naohiko ;
Ishimitsu, Toshihiko .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2012, 34 (03) :191-200
[9]   A crossover comparison of urinary albumin excretion as a new surrogate marker for cardiovascular disease among 4 types of calcium channel blockers [J].
Konoshita, Tadashi ;
Makino, Yasukazu ;
Kimura, Tomoko ;
Fujii, Miki ;
Morikawa, Norihiro ;
Wakahara, Shigeyuki ;
Arakawa, Kenichiro ;
Inoki, Isao ;
Nakamura, Hiroyuki ;
Miyamori, Isamu .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 166 (02) :448-452
[10]   Linking RAGE and Nox in diabetic micro- and macrovascular complications [J].
Koulis, C. ;
Watson, A. M. D. ;
Gray, S. T. ;
Jandeleit-Dahm, K. A. .
DIABETES & METABOLISM, 2015, 41 (04) :272-281
12