The expression of ERβ2, Bcl-xl and Bax in non-small cell lung cancer and associated with prognosis

被引：0
|
作者：
Liu, Junfeng [1 ]
Nie, Zhaoming [1 ]
Lei, Yiyan [2 ]
Yang, Shibin [3 ]
Liu, Zhaoguo [2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Thorac Surg, 58 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Estrogen receptors beta; non-small cell lung cancer; Bcl-xl; Bax; ESTROGEN-RECEPTOR-BETA; BREAST-CANCER; GENE-EXPRESSION; NUCLEAR; P53;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Lung cancer is now the leading cause of related death in the world, non-small lung cancer (NSCLC) in predominant type of lung cancer. In this study, we mainly discuss expression, distribution, and prognostic significance of ER beta 2, Bcl-xl and Bax in NSCLC. The expression of ER beta 2, Bcl-xl and Bax were detected by immunohistochemistry (IHC), and then the staining was evaluated and correlated with clinic and pathologic characteristics, overall survival (OS). ER beta 2, Bcl-xl and Bax were localized in NSCLC, and they were over-expressed all in NSCLC (P<0.05) compared with BPL tissues. IHC results showed that ER beta 2, Bcl-xl and Bax were not correlated with gender, age, smoking index, histological type, regional lymph node metastasis, whereas it was correlated with TNM staging of patients. In a Kaplan Meier analysis, the higher expression of ER beta 2, Bcl-xl and Bax was correlated with good OS. ER beta 2, Bcl-xl and Bax may be prognostic factors in NSCLC and useful to clinic trials.
引用
收藏
页码：10040 / 10046
页数：7
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