Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

被引:171
作者
Nair, Lekha [1 ]
Chung, Hachung [1 ]
Basu, Uttiya [1 ]
机构
[1] Columbia Univ, Vagelos Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA
关键词
AICARDI-GOUTIERES SYNDROME; MESSENGER-RNA; R-LOOPS; POLYMERASE-II; GENE-EXPRESSION; DNA-DAMAGE; TRANSCRIPTIONAL TERMINATION; PONTOCEREBELLAR HYPOPLASIA; SACCHAROMYCES-CEREVISIAE; DIVERGENT TRANSCRIPTION;
D O I
10.1038/s41580-019-0209-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Much of the mammalian genome is transcribed, generating long non-coding RNAs (lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the non-coding transcripts is allowed to attain sufficient stability to persist in the cellular milieu and control various cellular functions. Paralleling protein turnover by the proteasome complex, lncRNAs are also likely to exist in a dynamic equilibrium that is maintained through constant monitoring by the RNA surveillance machinery. In this Review, we describe the RNA surveillance factors and discuss the vital role of lncRNA surveillance in orchestrating various biological processes, including the protection of genome integrity, maintenance of pluripotency of embryonic stem cells, antibody-gene diversification, coordination of immune cell activation and regulation of heterochromatin formation. We also discuss examples of human diseases and developmental defects associated with the failure of RNA surveillance mechanisms, further highlighting the importance of lncRNA surveillance in maintaining cell and organism functions and health. Mammalian genomes generate long non-coding RNAs, which are degraded by the RNA surveillance machinery. This regulated degradation is vital for various processes, including for genome integrity, stem cell pluripotency and immune cell activation. Consequently, defects in RNA surveillance cause human diseases and developmental disorders.
引用
收藏
页码:123 / 136
页数:14
相关论文
共 180 条
  • [1] Genome instability:: a mechanistic view of its causes and consequences
    Aguilera, Andres
    Gomez-Gonzalez, Belen
    [J]. NATURE REVIEWS GENETICS, 2008, 9 (03) : 204 - 217
  • [2] DNA-RNA hybrids: the risks of DNA breakage during transcription
    Aguilera, Andres
    Gomez-Gonzalez, Belen
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017, 24 (05) : 439 - 443
  • [3] Transcription and Recombination: When RNA Meets DNA
    Aguilera, Andres
    Gaillard, Helene
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2014, 6 (08):
  • [4] R Loops: From Transcription Byproducts to Threats to Genome Stability
    Aguilera, Andres
    Garcia-Muse, Tatiana
    [J]. MOLECULAR CELL, 2012, 46 (02) : 115 - 124
  • [5] Functions of the exosome in rRNA, snoRNA and snRNA synthesis
    Allmang, C
    Kufel, J
    Chanfreau, G
    Mitchell, P
    Petfalski, E
    Tollervey, D
    [J]. EMBO JOURNAL, 1999, 18 (19) : 5399 - 5410
  • [6] Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes
    Alzu, Amaya
    Bermejo, Rodrigo
    Begnis, Martina
    Lucca, Chiara
    Piccini, Daniele
    Carotenuto, Walter
    Saponaro, Marco
    Brambati, Alessandra
    Cocito, Andrea
    Foiani, Marco
    Liberi, Giordano
    [J]. CELL, 2012, 151 (04) : 835 - 846
  • [7] ISOLATION AND CHARACTERIZATION OF RAT1 - AN ESSENTIAL GENE OF SACCHAROMYCES-CEREVISIAE REQUIRED FOR THE EFFICIENT NUCLEOCYTOPLASMIC TRAFFICKING OF MESSENGER-RNA
    AMBERG, DC
    GOLDSTEIN, AL
    COLE, CN
    [J]. GENES & DEVELOPMENT, 1992, 6 (07) : 1173 - 1189
  • [8] RNase H enables efficient repair of R-loop induced DNA damage
    Amon, Jeremy D.
    Koshland, Douglas
    [J]. ELIFE, 2016, 5
  • [9] An atlas of active enhancers across human cell types and tissues
    Andersson, Robin
    Gebhard, Claudia
    Miguel-Escalada, Irene
    Hoof, Ilka
    Bornholdt, Jette
    Boyd, Mette
    Chen, Yun
    Zhao, Xiaobei
    Schmidl, Christian
    Suzuki, Takahiro
    Ntini, Evgenia
    Arner, Erik
    Valen, Eivind
    Li, Kang
    Schwarzfischer, Lucia
    Glatz, Dagmar
    Raithel, Johanna
    Lilje, Berit
    Rapin, Nicolas
    Bagger, Frederik Otzen
    Jorgensen, Mette
    Andersen, Peter Refsing
    Bertin, Nicolas
    Rackham, Owen
    Burroughs, A. Maxwell
    Baillie, J. Kenneth
    Ishizu, Yuri
    Shimizu, Yuri
    Furuhata, Erina
    Maeda, Shiori
    Negishi, Yutaka
    Mungall, Christopher J.
    Meehan, Terrence F.
    Lassmann, Timo
    Itoh, Masayoshi
    Kawaji, Hideya
    Kondo, Naoto
    Kawai, Jun
    Lennartsson, Andreas
    Daub, Carsten O.
    Heutink, Peter
    Hume, David A.
    Jensen, Torben Heick
    Suzuki, Harukazu
    Hayashizaki, Yoshihide
    Mueller, Ferenc
    Forrest, Alistair R. R.
    Carninci, Piero
    Rehli, Michael
    Sandelin, Albin
    [J]. NATURE, 2014, 507 (7493) : 455 - +
  • [10] Biomolecular condensates: organizers of cellular biochemistry
    Banani, Salman F.
    Lee, Hyun O.
    Hyman, Anthony A.
    Rosen, Michael K.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2017, 18 (05) : 285 - 298