Transcutaneous Measurement of Glomerular Filtration Rate in conscious laboratory Animals: State of the Art and Future Perspectives

被引：0

作者：

Friedemann, Jochen ^{[1
]}

Schock-Kusch, Daniel ^{[1
]}

Shulhevich, Yury ^{[1
]}

机构：

[1] MediBeacon GmbH, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

来源：

REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS IX | 2017年 / 10079卷

关键词：

Transdermal; glomerular filtration rate; kidney; fluorescence; preclinical; RENAL-FUNCTION; FITC-SINISTRIN; MODEL;

D O I：

10.1117/12.2250887

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Transcutaneous measurement of Glomerular Filtration Rate (tGFR) is now frequently used in preclinical in vivo animal studies. tGFR allows consecutive measurements on the same animal, including multiple measurements on a daily basis. A description of the measurement device and its many applications, along with examples from the recent literature will be given. We will highlight the fields of interest in which the system is used and give an overview about its performance versus endogenous and other exogenous methods of GFR measurement. A special focus will be put on the precision of tGFR compared to standard measurements employed in the research setting.

引用

页数：9

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