The multifaceted aspects of refractory lupus nephritis

被引：15

作者：

Moroni, Gabriella ^{[1
]}

Ponticelli, Claudio ^{[2
]}

机构：

[1] Fdn Ca Granda Osped Maggiore IRCCS, Div Nephrol, I-20122 Milan, Italy

[2] Humanitas Clin & Res Ctr, Nephrol & Dialysis Unit, Milan, Italy

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2015年 / 11卷 / 02期

关键词：

lupus nephritis; nephritic flares; nephrotic syndrome; refractory nephritis; systemic lupus erythematosus; TERM-FOLLOW-UP; MYCOPHENOLATE-MOFETIL; IMMUNOSUPPRESSIVE THERAPY; PULSE METHYLPREDNISOLONE; PLUS CYCLOPHOSPHAMIDE; ORAL CYCLOPHOSPHAMIDE; MAINTENANCE THERAPY; PROGNOSTIC-FACTORS; INDUCTION THERAPY; REMISSION;

D O I：

10.1586/1744666X.2015.990883

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The term refractory lupus nephritis is generally used to indicate cases that do not respond to traditional treatment. However, the clinical presentation of lupus nephritis is variable and the time to response depends on the typology of the underlying renal syndrome. The criteria and the time for response are different in lupus patients with nephritic flares, in those with nephrotic syndrome, and in those with asymptomatic renal disease. In this paper, we will focus on the clinical characteristics, the consequences, and the possible therapeutic approaches for patients with different forms of refractory lupus nephritis, defined on the basis of renal syndrome at presentation.

引用

页码：281 / 288

页数：8

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