Synthesis of spirodienones by intramolecular ipso-cyclization of N-methoxy-(4-halogenophenyl)amides using [hydroxy(tosyloxy)iodo]benzene in trifluoroethanol

被引：60

作者：

Miyazawa, E ^{[1
]}

Sakamoto, T ^{[1
]}

Kikugawa, Y ^{[1
]}

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 13期

关键词：

D O I：

10.1021/jo034318w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spirodienones bearing the 1-azaspiro[4.5]decane ring system have been synthesized from N-methoxy-(4-halogenophenyl)amides by the intramolecular ipso attack of a nitrenium ion generated with [hydroxy(tosyloxy)iodo]-benzene in trifluoroethanol.

引用

页码：5429 / 5432

页数：4

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