Delivery strategies and potential targets for siRNA in major cancer types

被引：98
作者：
Lee, So Jin [1 ,2 ]
Kim, Min Ju [1 ,2 ,3 ]
Kwon, Ick Chan [2 ,3 ]
Roberts, Thomas M. [1 ]
机构：
[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[2] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Hwarangno 14 Gil 6, Seoul 136791, South Korea
[3] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 104卷
基金：
新加坡国家研究基金会;
关键词：
Small interfering RNA (siRNA); Delivery strategy of siRNAs; Cancer; siRNA therapeutics; Gene target; SMALL INTERFERING RNA; IN-VIVO DELIVERY; NANOPARTICLE-BASED DELIVERY; PROTEIN-KINASE CK2; BREAST-CANCER; SYSTEMIC DELIVERY; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA; POLYMERIZED SIRNA; TUMOR-GROWTH;
D O I：
10.1016/j.addr.2016.05.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to its ability to inhibit specific genes in many genetic diseases. For many years, studies of siRNA have progressively advanced toward novel treatment strategies against cancer. Cancer is caused by various mutations in hundreds of genes including both proto-oncogenes and tumor suppressor genes. In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed. In addition, we present current thinking on target gene selection in major tumor types. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：2 / 15
页数：14
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