Genetic control of longevity in C-elegans

被引:68
作者
Braeckman, Bart P. [1 ]
Vanfleteren, Jacques R. [1 ]
机构
[1] Univ Ghent, Dept Biol, B-9000 Ghent, Belgium
关键词
Caenorhabditis elegans; Ins/IGF signaling; daf-16; aging physiology;
D O I
10.1016/j.exger.2006.04.010
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The nematode Caenorhabditis elegans has proven to be a very useful too] for studying the genetics of longevity. Over 70 genes have been found to influence lifespan in this worm. Those related to the Ins/IGF signaling pathway are among the best studied and will be focused on in this review. The master regulator of this pathway, the forkhead transcription factor DAF-16, can activate an enhanced life maintenance program in response to environmental and gonadal inputs. DAF-16 up- and downregulates expression of many genes leading to metabolic alterations and increased stress and microbial resistance. This is generally confirmed by biochemical and physiological data. Longevity mutants are not hypometabolic and probably produce more reactive oxygen species than wild type. However, their high antioxidant capacity may result in lower oxidative damage. Enhanced molecular turnover rates may also play a role in their longevity phenotype. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:90 / 98
页数:9
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