NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

被引：129

作者：

Sahoo, Sanghamitra ^{[1
]}

Meijles, Daniel N. ^{[1
]}

Pagano, Patrick J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Vasc Med Inst, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA

来源：

CLINICAL SCIENCE | 2016年 / 130卷 / 05期

基金：

美国国家卫生研究院;

关键词：

aging; cardiovascular diseases; reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase; reduced nicotinamide-adenine dinucleotide phosphate oxidase therapeutics (Nox therapeutics); GROWTH-FACTOR-I; SMOOTH-MUSCLE-CELLS; VASCULAR OXIDATIVE STRESS; PULMONARY ARTERIAL-HYPERTENSION; NOX FAMILY PROTEINS; LIFE-SPAN; REACTIVE OXYGEN; ATRIAL-FIBRILLATION; NAD(P)H OXIDASE; SUPEROXIDE-PRODUCTION;

D O I：

10.1042/CS20150087

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of 'longevity genes' and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population.

引用

页码：317 / 335

页数：19

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