Regulation of neutrophil functions by proinflammatory cytokines

被引：61

作者：

Kato, Takayuki ^{[1
]}

Kitagawa, Seiichi ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Physiol, Abeno Ku, Osaka 5458585, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2006年 / 84卷 / 03期

关键词：

neutrophil; cytokine; superoxide; migration; apoptosis;

D O I：

10.1532/IJH97.06141

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Various functions of mature human neutrophils are activated or potentiated by hematopoietic growth factors or proinflammatory cytokines such as granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor alpha, and interleukin 1 beta. The major signaling pathways activated in human neutrophils stimulated by proinflammatory cytokines include mitogen-activated protein kinases, Janus kinase/signal transducer and activator of transcription, phosphatidylinositol 3-kinase, and nuclear factor kappa B. These signaling pathways are involved in cytokine-mediated regulation of neutrophil functions in a cytokine-specific manner.

引用

页码：205 / 209

页数：5

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