Evaluating Aztreonam and Ceftazidime Pharmacodynamics with Escherichia coli in Combination with Daptomycin, Linezolid, or Vancomycin in an In Vitro Pharmacodynamic Model

被引：22

作者：

LaPlante, Kerry L. ^{[1
,2
]}

Sakoulas, George ^{[3
,4
,5
]}

机构：

[1] Univ Rhode Isl, Dept Pharm Practice, Kingston, RI 02881 USA

[2] Vet Affairs Med Ctr, Providence, RI USA

[3] New York Med Coll, Div Infect Dis, Valhalla, NY 10595 USA

[4] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

[5] Sharp Mem Hosp & Rehabil Ctr, San Diego, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

关键词：

HEALTHY-VOLUNTEERS; PHARMACOKINETICS; CHLORAMPHENICOL; OXAZOLIDINONES; PENETRATION; SIMULATION; RESISTANCE; SYNERGY;

D O I：

10.1128/AAC.00180-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.

引用

页码：4549 / 4555

页数：7

共 29 条

[1] ANTAGONISTIC EFFECT OF CHLORAMPHENICOL IN COMBINATION WITH CEFOTAXIME OR CEFTRIAXONE
ASMAR, BI
PRAINITO, M
DAJANI, AS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) : 1375 - 1378
[2] PENETRATION OF AZTREONAM INTO HUMAN BRONCHIAL-SECRETIONS
BECHARD, DL
HAWKINS, SS
DHRUV, R
FRIEDHOFF, LT
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (02) : 263 - 264
[3] INVITRO MODEL FOR SIMULTANEOUS SIMULATION OF THE SERUM KINETICS OF 2 DRUGS WITH DIFFERENT HALF-LIVES
BLASER, J
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1985, 15 : 125 - 130
[4] PHARMACOKINETICS AND SERUM BACTERICIDAL ACTIVITY OF VANCOMYCIN ALONE AND IN COMBINATION WITH CEFTAZIDIME IN HEALTHY-VOLUNTEERS
BOECKH, M
LODE, H
BORNER, K
HOFFKEN, G
WAGNER, J
KOEPPE, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (01) : 92 - 95
[5] Comparison of methods of interpretation of checkerboard synergy testing
Bonapace, CR
Bosso, JA
Friedrich, LV
White, RL
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2002, 44 (04) : 363 - 366
[6] Clinical and Laboratory Standards Institute, 2006, METH DIL ANT SUSC TE, V7
[7] Clinical and Laboratory Standards Institute, 2008, M100S18 CLIN LAB STA
[8] Daptomycin pharmacokinetics and safety following administration of escalating doses once daily to healthy subjects
Dvorchik, BH
Brazier, D
DeBruin, MF
Arbeit, RD
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (04) : 1318 - 1323
[9] Eliopoulos G M, 1989, Infect Dis Clin North Am, V3, P399
[10] Pharmacokinetics and tissue penetration of linezolid following multiple oral doses
Gee, T
Ellis, R
Marshall, G
Andrews, J
Ashby, J
Wise, R
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) : 1843 - 1846

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