CD30+ Lymphoproliferative Disorders of the Skin

被引：28
作者：
Sauder, Maxwell B. [1 ]
O'Malley, John T. [1 ]
LeBoeuf, Nicole R. [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Dermatol,Ctr Cutaneous Oncol, 450 Brookline Ave, Boston, MA 02115 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 31卷 / 02期
关键词：
CD30(+); Cutaneous lymphoproliferative disorders; Lymphomatoid papulosis; Primary cutaneous anaplastic large cell lymphoma; Secondary cutaneous anaplastic large cell lymphoma; LARGE-CELL LYMPHOMA; FACTOR-KAPPA-B; PAPULOSIS; EXPRESSION; CLASSIFICATION; RECEPTOR; LIGAND; PROLIFERATION; PSEUDOLYMPHOMA; MALIGNANCIES;
D O I：
10.1016/j.hoc.2016.11.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary cutaneous CD30+ lymphoproliferative disorders encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and indeterminate cases. LyP is a benign disorder characterized by recurrent crops of red or violaceous papulonodules. Patients with LyP are at an increased risk of a secondary malignancy. pcALCL is characterized by a solitary red to violaceous nodule or tumor larger than 20 mm. LyP is benign, is limited to the skin, and self-resolves, with a 5-year survival rate of 100%; pcALCL is limited to the skin and responsive to directed therapies, with a 5-year survival rate of over 95%. Aggressive chemotherapeutic regimens should be avoided. © 2017 Elsevier Inc.
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页码：317 / +
页数：19
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