Synthesis and antimicrobial and antifungal activities of compounds of the naphthazarin series

被引：14

作者：

Yakubovskaya, A. Ya. ^{[1
]}

Pokhilo, N. D. ^{[1
]}

Anufriev, V. F. ^{[1
]}

Anisimov, M. M. ^{[1
]}

机构：

[1] Pacific Ocean Inst Bioorgan Chem, Vladivostok, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 07期

关键词：

5,8-Dihydroxy-1,4-naphthoquinone; naphthazarin; antimicrobial activity; Saccharomyces carlsbergensis; Staphylococcus aureus; Escherichia coli;

D O I：

10.1007/s11094-009-0322-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted naphthazarins (5,8-dihydroxy-1,4-naphthoquinones) were synthesized and their antimicrobial and antifungal activities were studied. The yeast Saccharomyces carlsbergensis was the most sensitive to these compounds. Among the compounds studied, the most marked antimicrobial and antifungal activities were obtained with unsubstituted naphthazarin, which was as active as juglone.

引用

页码：396 / 398

页数：3

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