Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis

被引：49
作者：
Jiang, Huan [1 ]
Zhang, Gui-Jie [2 ]
Liu, Yan-Fei [3 ,4 ]
Wang, Heng-Shan [1 ]
Liang, Dong [1 ]
机构：
[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Sch Chem & Pharmaceut Sci, Guilin 541004, Peoples R China
[2] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 04期
基金：
中国国家自然科学基金;
关键词：
NITRIC-OXIDE; GLYCOSIDE; RHIZOMES; ROOTS;
D O I：
10.1021/acs.jnatprod.6b00976
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ten new clerodane diterpenoittglucosides (1-10) and three known analogues (11-13) were isolated from an EtOAc extract of the stems of Tinospora sinensis. Spectroscopic analyses and chemical methods were used to elucidate the structures of these isolates. The absolute configurations of :tinosinenosides A-C (1-3) were established by using experimental arid calculated ECD data. Their cytotoxicity against the human epithelioid cervical carcinoma (HeLa) cell line and the nitric oxide production inhibitory activity of lipopolysaccharide-activated N9 microglial tells were tested. 1-Deacetyltinosposide A (12) exhibited mild rytotoxicity against HeLa cells, with an IC50 value of 8.35 +/- 0.60 mu M.
引用
收藏
页码：975 / 982
页数：8
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