Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats

被引：54
作者：
Buchenauer, T. [1 ]
Behrendt, P. [1 ]
Bode, F. J. [1 ]
Horn, R. [2 ]
Brabant, G. [3 ]
Stephan, M. [1 ,4 ]
Nave, H. [1 ]
机构：
[1] Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany
[2] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
[3] Christie Hosp, Dept Endocrinol, Manchester, Lancs, England
[4] Hannover Med Sch, Clin Psychosomat & Psychotherapy, D-30625 Hannover, Germany
来源：
PHYSIOLOGY & BEHAVIOR | 2009年 / 98卷 / 05期
关键词：
Obesity; Behavior; Anxiety; Aggression; Glucocorticoids; HIGHLY PALATABLE DIET; SOCIAL-INTERACTION; ENERGY-BALANCE; LEPTIN; BRAIN; MICE; CONSUMPTION; ANXIETY; MODEL; ANTAGONIST;
D O I：
10.1016/j.physbeh.2009.09.003
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Obesity is an increasing socio-economic health problem. Diet-induced obese (DID) rodents are widely used as a model of obesity in humans. However, there is no comprehensive data about the behavioral phenotype of DID rodents. Therefore. the aim of the present study was to determine whether a high-fat-diet changes behavioral patterns of DIO Fischer 344 (F344) rats in comparison with lean littermates. The behavioral tests (homecage, holeboard, social interaction, and hotplate) were performed in 28 normal-weight and 28 male DD F344 rats (mean age: 16 weeks) and revealed a significantly higher level of anxiety- and aggression-related parameters in obese rats, whereas their pain threshold was significantly lower. Fitting to a different behavioral response. basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0 ng/ml vs. 12.5 ng/ml; p < 0.01). We conclude that obese rats differ in various aspects from their lean littermates. The altered behavioral characteristics displayed by DID F344 rats have to be considered in further experiments involving DIO rodents. (C) 2009 Elsevier Inc. All rights reserved.
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收藏
页码：563 / 569
页数：7
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