Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke

被引：8
|
作者：
Mnafgui, Kais [1 ]
Khdhiri, Emna [2 ]
Ghazouani, Lakhdar [3 ]
Ncir, Marwa [1 ]
Zaafouri, Zouhaier [4 ]
Allouche, Noureddine [5 ]
Elfeki, Abdelfattah [1 ]
Ammar, Houcine [2 ]
Abid, Souhir [2 ,6 ]
Hajji, Raouf [7 ]
机构：
[1] Univ Sfax, Fac Sci Sfax, Lab Anim Physiol, POB 95, Sfax 3052, Tunisia
[2] Univ Sfax, Fac Sci, Lab Appl Chem HCGP, Sfax, Tunisia
[3] Fac Sci Gafsa, Res Unit Macromol Biochem & Genet, Gafsa, Tunisia
[4] Hosp Sidi Bouzid, Dept Surg, Sidi Bouzid, Tunisia
[5] Univ Sfax, Lab Organ Chem LR17ES08 Nat, Nat Subst Team, Fac Sci Sfax, Sfax, Tunisia
[6] Jouf Univ, Coll Sci & Arts, Chem Dept, Al Jawf, Saudi Arabia
[7] Hosp Sidi Bouzid, Dept Internal Med, Fac Med Sousse, Sidi Bouzid, Tunisia
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2021年 / 127卷 / 06期
关键词：
Stroke; atrial flutter; myocardial infarction; fibrinogen; coumarin; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; ARTERIAL THROMBOSIS; ATRIAL-FIBRILLATION; LIPID-PEROXIDATION; CEREBRAL-ISCHEMIA; TROPONIN-T; MORTALITY; BRAIN; CLASSIFICATION;
D O I：
10.1080/13813455.2019.1657900
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to evaluate the cerebroprotective potential of a novel synthetic coumarin, (E)-4-amino-N '-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene) benzohydrazide noted (HC) against a pharmaceutically induced ischemic stroke in experimental male Wistar rats. Animals were randomly allocated into four groups: control, Stroke, Stroke + Ace (acenocoumarol) and Stroke + HC-treated group for 7 days. Our results showed that stroke group evidenced atrial flutter, significant cardiac hypertrophy (+23%) and increase in plasma level of troponin-T, with disturbance in plasma ionic levels and rise in fibrinogen rate and oxidative damages in heart and brain. Moreover, the histological findings revealed myocardium necrosis, cardiac cavity thrombi and brain injury as compared to normal rats. However, HC-treatment significantly prevents the embolic process, improves cerebral damages and mitigates the oxidative stress markers in stroke rats. Overall, HC is endowed with a thrombolytic potential against MI and stroke in such severe conditions through an anti-vit K (AVK) mechanism.
引用
收藏
页码：527 / 540
页数：14
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