Linking axon morphology to gene expression: a strategy for neuronal cell-type classification

被引:4
作者
Winnubst, Johan [1 ]
Spruston, Nelson [1 ]
Harris, Julie A. [2 ,3 ]
机构
[1] Howard Hughes Med Inst, Janelia Res Campus, Ashburn, VA 20147 USA
[2] Allen Inst Brain Sci, Seattle, WA 98109 USA
[3] Cajal Neurosci, Seattle, WA 98102 USA
关键词
PATHWAYS; CONNECTIVITY; INFORMATION; NETWORKS; CORTEX;
D O I
10.1016/j.conb.2020.10.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To study how the brain drives cognition and behavior we need to understand its cellular composition. Advances in single-cell transcriptomics have revolutionized our ability to characterize neuronal diversity. To arrive at meaningful descriptions of cell types, however, gene expression must be linked to structural and functional properties. Axonal projection patterns are an appropriate measure, as they are diverse, change only gradually over time, and they influence and constrain circuit function. Here, we consider how efforts to map transcriptional and morphological diversity in the mouse brain could be linked to generate a modern taxonomy of the mouse brain.
引用
收藏
页码:70 / 76
页数:7
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