Twenty-two cases of neuromeningeal cryptococcosis in Tunisia

被引：6

作者：

Kaouech, E. ^{[1
]}

Kallel, K. ^{[1
]}

Belhadj, S. ^{[1
]}

Anane, S. ^{[1
]}

Ben Chaabane, T. ^{[2
]}

Ben Fadhl, K. ^{[3
]}

Khedher, A. ^{[4
]}

Meddeb, B. ^{[5
]}

Ben Lakhal, S. ^{[6
]}

Chaker, E. ^{[1
]}

机构：

[1] Hop La Rabta, Lab Parasitol Mycol, Tunis 1007, Tunisia

[2] Hop La Rabta, Serv Malad Infect, Tunis 1007, Tunisia

[3] Hop Habib Thameur, Serv Anesthesie Reanimat, Tunis, Tunisia

[4] Hop Charles Nicolle, Serv Med Interne M8, Tunis, Tunisia

[5] Hop Aziza Othmana, Serv Hematol, Tunis, Tunisia

[6] Hop La Rabta, Serv Reanimat Med, Tunis 1007, Tunisia

来源：

MEDECINE ET MALADIES INFECTIEUSES | 2009年 / 39卷 / 12期

关键词：

Cryptococcus neoformans; Neuromeningeal cryptococcosis; Immunodepression; AIDS; COMBINATION; MENINGITIS; NEOFORMANS;

D O I：

10.1016/j.medmal.2009.02.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Neuromeningeal cryptococcosis is a serious infection witch occurs essentially in immunodepressed patients and especially AIDS patients. We report 22 cases of cryptococcosis meningitis confirmed by the parasitology laboratory, in the Tunis Rabta hospital, over a 16-year period. Sixteen patients were HIV infected and six were not HIV infected. The clinical examination documented fever and headache as well as focal neurological signs especially in HIV infected patients. The mycological examination of CSF proved the diagnosis of neuromeningeal cryptococcosis in all cases. The first line treatment was Amphotericin B in 13 cases, Amphotericin B and 5Fluorocytosine in three cases, and fluconazole in six cases. 14 patients died, seven recovered, and one was lost to follow-up. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：914 / 919

页数：6

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