Particle engulfment by strongly asymmetric membranes with area reservoirs

被引:8
作者
Agudo-Canalejo, Jaime [1 ]
机构
[1] Max Planck Inst Dynam & Self Org MPIDS, D-37077 Gottingen, Germany
关键词
CORTICAL TENSION; VIRUS ENTRY; NANOPARTICLES; VESICLES; CURVATURE; MECHANICS; DELIVERY; CONTACT; SHAPE; SIZE;
D O I
10.1039/c9sm02367d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Biological cells are capable of undergoing extensive shape transformations thanks to the existence of membrane area reservoirs from which they can pull out membrane when required. A particularly relevant example of such membrane remodelling is given by endocytic and phagocytic processes, during which the cell membrane engulfs nano- and micrometer sized particles. Recently, it was shown that cell-like membrane reservoirs can be mimicked in giant vesicles with nanotubes stabilized by strong bilayer asymmetry, as quantified by the membrane's spontaneous curvature. Here, we theoretically investigate particle engulfment by such strongly-asymmetric membranes. We find that, depending on the sign of the spontaneous curvature, the engulfment transition may be continuous or discontinuous. Moreover, we find that, in the case of particle engulfment, the presence of asymmetry-stabilized reservoirs is not well captured by the constant-tension model typically used to describe cell-membrane deformations. This highlights the need for a better understanding of the nature of cellular membrane reservoirs, in order to accurately describe membrane remodelling processes.
引用
收藏
页码:298 / 307
页数:10
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