Traditional Chinese Medicine and Herb-induced Liver Injury: Comparison with Drug-induced Liver Injury
被引:79
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作者:
Jing, Jing
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机构:
Med Sch Chinese PLA, Beijing, Peoples R China
302 Mil Hosp, Integrat Med Ctr, Beijing, Peoples R ChinaMed Sch Chinese PLA, Beijing, Peoples R China
Jing, Jing
[1
,2
]
Teschke, Rolf
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机构:
Goethe Univ, Teaching Hosp, Klinikum Hanau,Div Gastroenterol & Hepatol, Med Fac,Dept Internal Med 2, Frankfurt, GermanyMed Sch Chinese PLA, Beijing, Peoples R China
Teschke, Rolf
[3
]
机构:
[1] Med Sch Chinese PLA, Beijing, Peoples R China
[2] 302 Mil Hosp, Integrat Med Ctr, Beijing, Peoples R China
[3] Goethe Univ, Teaching Hosp, Klinikum Hanau,Div Gastroenterol & Hepatol, Med Fac,Dept Internal Med 2, Frankfurt, Germany
Cases of suspected herb-induced liver injury (HILI) caused by herbal Traditional Chinese Medicines (TCMs) and of drug-induced liver injury (DILI) are commonly published in the scientific literature worldwide. As opposed to the multiplicity of botanical chemicals in herbal TCM products, which are often mixtures of several herbs, conventional Western drugs contain only a single synthetic chemical. It is therefore of interest to study how HILI by TCM and DILI compare with each other, and to what extent results from each liver injury type can be transferred to the other. China is among the few countries with a large population using synthetic Western drugs as well as herbal TCM. Therefore, China is well suited to studies of liver injury comparing drugs with TCM herbs. Despite some concordance, recent analyses of liver injury cases with verified causality, using the Roussel Uclaf Causality Assessment Method, revealed major differences in HILI caused by TCMs as compared to DILI with respect to the following features: HILI cases are less frequently observed as compared to DILI, have a smaller proportion of females and less unintentional rechallenge events, and present a higher rate of hepatocellular injury features. Since many results were obtained among Chinese residents who had access to and had used Western drugs and TCM herbs, such ethnic homogeneity supports the contention that the observed differences of HILI and DILI in the assessed population are well founded.
机构:
Beijing 302 Hosp China, Beijing, Peoples R China
China Natl Advisory Council Tradit Chinese Medici, Beijing, Peoples R ChinaBeijing 302 Hosp China, Beijing, Peoples R China
Wang, J. -B.
Guo, Y. -M.
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Beijing 302 Hosp China, Beijing, Peoples R ChinaBeijing 302 Hosp China, Beijing, Peoples R China
Guo, Y. -M.
Xiao, X. -H.
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Beijing 302 Hosp China, Beijing, Peoples R China
China Natl Advisory Council Tradit Chinese Medici, Beijing, Peoples R ChinaBeijing 302 Hosp China, Beijing, Peoples R China
机构:
Capital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R ChinaCapital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R China
Ma, Zhi-Tao
Shi, Zhuo
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Peoples Liberat Army Gen Hosp, Med Ctr 5, China Mil Inst Chinese Med, Beijing, Peoples R ChinaCapital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R China
Shi, Zhuo
Xiao, Xiao-He
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Peoples Liberat Army Gen Hosp, Med Ctr 5, China Mil Inst Chinese Med, Beijing, Peoples R China
Peoples Liberat Army Gen Hosp, Med Ctr 5, China Mil Inst Chinese Med, Beijing 100039, Peoples R ChinaCapital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R China
Xiao, Xiao-He
Wang, Jia-Bo
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Capital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R China
Capital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing 100069, Peoples R ChinaCapital Med Univ, Sch Tradit Chinese Med, Dept Pharmaceut Chinese Mat Med, Beijing, Peoples R China
机构:
Univ South Wales, Post Grad Program Acute Med & Gastroenterol, Cardiff CF37 1DL, Wales
Univ South Wales, Post Grad Program Acute Med & Gastroenterol, Llantwit Rd, Cardiff CF37 1DL, WalesUniv South Wales, Post Grad Program Acute Med & Gastroenterol, Cardiff CF37 1DL, Wales
机构:
China Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Zhang, L.
Mao, Y. M.
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Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai 200030, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Mao, Y. M.
Teschke, R.
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Goethe Univ Frankfurt Main, Fac Med, Teaching Hosp, Frankfurt, GermanyChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Teschke, R.
Yang, X. H.
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机构:
Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Yang, X. H.
Wu, S. X.
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Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Wu, S. X.
Long, H. Z.
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Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Long, H. Z.
Meyboom, R.
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Univ Utrecht, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, NetherlandsChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
Meyboom, R.
Gao, X. M.
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机构:
Univ Chinese Med, Beijing, Peoples R ChinaChina Food & Drug Adm CFDA, Natl Ctr ADR Monitoring, Ctr Drug Reevaluat, Beijing, Peoples R China
机构:
302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China
Wang Jia-bo
Zhu Yun
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302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China
Zhu Yun
Bai Zhao-fang
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302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China
Bai Zhao-fang
Wang Fu-sheng
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302 Mil Hosp China, Res Ctr Biol Therapy, Beijing 100039, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China
Wang Fu-sheng
Li Xiu-hui
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机构:
Capital Med Univ, Beijing YouAn Hosp, Integrat Med Ctr, Beijing 100069, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China
Li Xiu-hui
Xiao Xiao-he
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302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China302 Mil Hosp China, Integrat Med Ctr, Beijing 100039, Peoples R China