Comparative activity of ertapenem against extended-spectrum beta lactamase-producing or plasmid-mediated AmpC beta lactamase-producing Klebsiella pneumoniae

被引：3

作者：

Ramon Hernandez, Jose ^{[1
]}

del Carmen Conejo, Maria ^{[1
]}

Pascual, Alvaro ^{[1
,2
]}

机构：

[1] Univ Seville, Fac Med, Dept Microbiol, Seville, Spain

[2] Hosp Univ Virgen Macarena, Dept Microbiol, Seville, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2010年 / 28卷 / 01期

关键词：

Ertapenem; Extended-spectrum beta-lactamase; Plasmid AmpC; Porin; Inoculum effect; IN-VIVO DEVELOPMENT; ESCHERICHIA-COLI; CLINICAL ISOLATE; RESISTANCE; COMBINATION; GENES;

D O I：

10.1016/j.eimc.2009.03.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: The effect of porin loss and inoculum size on the comparative activity of ertapenem against either extended-spectrum beta lactamase-producing (ESBL) or plasmid-mediated AmpC beta lactamase-producing (pACBL) Klebsiella pneumoniae strains was evaluated. Methods: Microdilution using 2 different bacterial inocula. Results: Imipenem, amikacin, ertapenem, and cefepime were the most active agents under standard conditions. Ertapenem was more highly affected by porin loss than imipenem. Conclusions: Ertapenem showed high activity against K. pneumoniae strains expressing ESBL, pACBL OF both. Strains deficient in porins showed decreased susceptibility to beta lactams. The inoculum effect had a greater impact on imipenem than on ertapenem. (C) 2008 Elsevier Espana, S.L. All rights reserved.

引用

页码：27 / 30

页数：4

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